Author

S. Leung

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5 Cell Biology· 2 Microbiology· 2 Ecology· 1 Immunology· 1 Pathology· 1

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Approach:experimental assay· 8 Research Focus:cell type annotation· 7 Research Focus:differential expression· 6 Organism:human· 6 Research Focus:host-pathogen & immune response· 4 Approach:statistical model· 4 Organism:rat· 3 Assay:whole-genome sequencing· 3

Frequent Co-Authors

E. Brunt· 3 shared E. Havasov· 3 shared F. Uhlitz· 3 shared H. E. Humphries· 3 shared K. A. Ryan· 3 shared K. R. Bewley· 3 shared L. Allen· 3 shared L. Hunter· 3 shared

Activity by Year

2019-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersMicrobiology

E. Brunt

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Author profile →

12 papers

Recent·Most cited

Palmitic acid reduces viability and increases production of reactive oxygen species and respiration in rat tendon-derived cells

S. Konar, C. P. Hedges, K. E. Callon, S. M. Bolam, S. Leung, J. Cornish, D. Naot, D. S. Musson

This study shows that palmitic acid reduces viability and increases ROS and respiration in rat tendon-derived cells, with partial reversal upon blocking mitochondrial uptake.

bioRxiv · Feb 8, 2023 · PreprintCell Biology

Immune and malignant cell phenotypes of ovarian cancer are determined by distinct mutational processes

I. Vazquez-Garcia, F. Uhlitz, N. Ceglia, J. L. P. Lim, M. Wu, N. Mohibullah, A. E. B. Ruiz, K. M. Boehm, V. Bojilova, C. J. Fong, T. Funnell, D. Grewal, E. Havasov, S. Leung, A. Pasha, , Nikolovsk

This study identifies distinct immune and malignant cell phenotypes in ovarian cancer linked to specific mutational processes and anatomic sites.

bioRxiv · Aug 24, 2021Cancer Biology

Matrix stiffness controls ciliogenesis and centriole position

I. Williantarra, S. Leung, Y. S. Choi, A. Chhana, S. R. McGlashan

This study shows that substrate stiffness affects cilia length and centriole position in chondrocytes, highlighting tissue-specific mechanosensing and its role in mechanosignalling.

bioRxiv · Aug 12, 2021 · PreprintCell Biology

Evolutionary tracking of cancer haplotypes at single-cell resolution

M. J. Williams, T. Funnell, C. O'Flanagan, A. McPherson, S. Salehi, I. Vazquez-Garcia, F. Kabeer, H. Lee, T. Masud, P. Eirew, D. Yap, B. Wang, J. Brimhall, J. Biele, J. Ting, , S. P. Shah

The paper tracks cancer haplotypes at single-cell resolution, revealing allele-specific alterations and their role in structural variation evolution in human tumors.

bioRxiv · Jun 4, 2021 · PreprintCancer Biology

The impact of mutational processes on structural genomic plasticity in cancer cells

T. Funnell, C. H. O'Flanagan, M. J. Williams, A. McPherson, S. McKinney, F. Kabeer, H. Lee, T. Masud, P. Eirew, D. Yap, A. W. Zhang, J. L. P. Lim, B. Wang, J. Brimhall, J. Biele, , S. Aparicio

The paper analyzes structural genomic variations in cancer cells to understand how mutational processes influence cell-to-cell genomic diversity and tumor evolution.

bioRxiv · Jun 3, 2021 · PreprintCancer Biology

Dose-dependent response to infection with SARS-CoV-2 in the ferret model: evidence of protection to re-challenge

K. A. Ryan, K. R. Bewley, S. A. Fotheringham, P. Brown, Y. Hall, A. C. Marriott, J. A. Tree, L. Allen, M. J. Aram, E. Brunt, K. R. Buttigieg, B. E. Cavell, D. P. Carter, R. Cobb, N. S. Coombes, , M Dennis

This study investigates the dose-dependent response of ferrets to SARS-CoV-2 infection, showing protection against re-challenge and mild clinical disease.

Nature Communications · Jan 4, 2021Peer-reviewedMicrobiology

Immunological and pathological outcomes of SARS-CoV-2 challenge after formalin-inactivated vaccine immunisation of ferrets and rhesus macaques

K. R. Bewley, K. E. R. Gooch, K. M. Thomas, S. R. Longet, N. Wiblin, L. Hunter, K. Chan, P. Brown, R. A. Russell, C. Ho, G. Slack, H. E. Humphries, L. Alden, L. Allen, M. Aram, , M. Carroll

This study evaluates vaccine-enhanced disease in ferrets and rhesus macaques after formalin-inactivated SARS-CoV-2 vaccination, finding mild transient lung pathology but no significant enhancement.

bioRxiv · Dec 21, 2020Pathology

Comparison of Rhesus and Cynomolgus macaques as an authentic model for COVID-19.

F. J. Salguero, A. D. White, G. S. Slack, S. A. Fotheringham, K. R. Bewley, K. E. Gooch, S. Longet, H. E. Humphries, R. J. Watson, L. Hunter, K. A. Ryan, Y. Hall, L. Sibley, C. Sarfas, L. Allen, , Tr

This study compares rhesus and cynomolgus macaques as models for mild to moderate COVID-19, showing similar viral replication, immune responses, and histopathology.

bioRxiv · Sep 17, 2020Microbiology

ENSO drives lateral separation of FAD-associated skipjack and bigeye tuna in the Western Tropical Pacific

S. Leung, K. A. S. Mislan, L. Thompson

The paper assesses lateral separation of skipjack and bigeye tuna in FAD-associated fisheries, finding ENSO-driven variations in their catch ratios that could inform fisheries management.

bioRxiv · Jun 25, 2020 · PreprintEcology

Primary platinum resistance and immune exclusion in ovarian carcinomas with high expression of the homologous recombination mediator RAD51

M. M. Hoppe, T. Z. Tan, S. Lie, S. Lim, J. P. Yeong, J. D. Wardyn, P. Jaynes, D. G. Lim, B. N. Pang, A. Karnezis, D. Chiu, S. Leung, D. G. Huntsman, A. S. Sedukhina, K. Sato, , A. Jeyasekharan

This study shows that high RAD51 expression in ovarian cancer is linked to poor survival and platinum resistance, particularly in HRD-negative tumors, and correlates with immune exclusion.

bioRxiv · Jun 9, 2020Cancer Biology

Expansion of Functional Regulatory T Cells Using Soluble RAGE Prevents Type 1 Diabetes

S. Leung, D. J. Borg, D. A. McCarthy, T. Boursalian, J. Cracraft, A. Zhuang, A. Fotheringham, N. Flemming, T. Watkins, J. Miles, P.-H. Groop, J. Scheijen, C. Schalkwijk, R. Steptoe, K. Radford, , J. M. Forbes

This study shows that soluble RAGE (sRAGE) expands functional regulatory T cells and prevents type 1 diabetes in mice and human T cells.

bioRxiv · Jan 10, 2020Immunology

Arginine depletion through ADI-PEG20 to treat argininosuccinate synthase deficient ovarian cancer, including small cell carcinoma of the ovary, hypercalcemic type

J. X. Ji, D. R. Cochrane, B. Tessier-Cloutier, S. Chen, G. Ho, K. V. Pathak, I. Alcazar, D. Farnell, S. Leung, A. Cheng, C. Chow, S. Colborne, G. Luca Negri, F. Kommoss, A. N. Karnezis, , D. G. Huntsman

This paper identifies ASS1 deficiency in rare ovarian cancers and shows that ADI-PEG20 inhibits tumor growth in ASS1-deficient models.

bioRxiv · Nov 17, 2019 · PreprintCancer Biology