Author

G. Ruan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Assay:proteomics· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:benchmarking· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:metagenomics· 1

Frequent Co-Authors

J. Zhu· 2 shared R. Sun· 2 shared T. Guo· 2 shared T. Zhu· 2 shared X. Cai· 2 shared X. Yi· 2 shared Y. J. Zhu· 2 shared A. Christiansen· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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2 shared papersMicrobiology

J. Zhu

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Gut microbiota-derived gamma-aminobutyric acid from metformin treatment reduces hepatic ischemia/reperfusion injury through inhibiting ferroptosis

F. Wang, X. Liu, F. Huang, Y. Zhou, X. Wang, Z. Song, S. Wang, X. Wang, D. Shi, G. Ruan, X. Ji, E. Zhang, Z. Tan, Y. Ye, C. Wang, , W. Wang

This study shows metformin reduces hepatic ischemia/reperfusion injury by altering gut microbiota to increase GABA, which inhibits ferroptosis.

bioRxiv · Jun 2, 2023Microbiology

Secreted ORF8 is a pathogenic cause of severe Covid-19 and potentially targetable with select NLRP3 inhibitors

X. Wu, M. K. Manske, G. Ruan, T. L. Witter, K. E. Nowakowski, J. P. Abeykoon, X. Tang, Y. Yu, K. A. Gwin, A. Wu, V. Taupin, V. Bhardwaj, J. Paludo, S. Dasari, H. Dong, , T. E. Witzig

This study identifies ORF8 as a secreted glycoprotein that drives severe COVID-19 through NLRP3 inflammasome activation and shows it is inhibited by MCC950.

bioRxiv · Dec 2, 2021Immunology

PulseDIA: in-depth data independent acquisition mass spectrometry using enhanced gas phase fractionation

X. Cai, W. Ge, X. Yi, R. Sun, J. Zhu, C. Lu, P. Sun, T. Zhu, G. Ruan, C. Yuan, S. Liang, M. Lyu, S. Huang, Y. J. Zhu, T. Guo

PulseDIA improves DIA-MS specificity and sensitivity by using gas phase fractionation, achieving higher protein identification rates in cancer proteomics.

bioRxiv · Sep 30, 2019 · PreprintBiochemistry

High-throughput proteomic analysis of FFPE tissue samples facilitates tumor stratification

Y. J. Zhu, T. Weiss, Q. Zhang, R. Sun, B. Wang, Z. Wu, Q. Zhong, X. Yi, H. Gao, X. Cai, G. Ruan, T. Zhu, C. Xu, S. Lou, X. Yu, , T. Guo

This study develops a proteomic workflow for FFPE tissues to stratify prostate cancer and DLBCL samples, identifying MPO as a prognostic marker and showing FFPE's utility for biomarker discovery.

bioRxiv · Jun 11, 2019Biochemistry