M. Lyu

Monocytic fibrocyte-like cell enrichment and myofibroblastic adaptation causes nucleus pulposus fibrosis and associates with disc degeneration severity

The paper identifies fibrocyte-like cells as key drivers of nucleus pulposus fibrosis in disc degeneration, showing their role in myofibroblast formation and disease severity.

The structure of the teleost Immunoglobulin M core provides insights on polymeric antibody evolution, assembly, and function

The paper reports the cryo-EM structure of teleost IgM, revealing a unique assembly mechanism distinct from mammalian IgM and highlighting evolutionary diversity in pIg structure and function.

Proteomic-based stratification of intermediate-risk prostate cancer patients

The paper identifies an 18-protein signature from proteomic data to stratify intermediate-risk prostate cancer patients into low- and high-risk groups for biochemical recurrence.

Droplet microfluidics forward for tracing target cells at single-cell transcriptome resolution

This paper develops a droplet-based method for single-cell transcriptome profiling of TCR-T cells, improving recovery and reducing contamination.

Gibberellins promote polar auxin transport to regulate stem cell fate decisions in cambium

This study shows gibberellins regulate stem cell fate in vascular cambium by modulating auxin transport, affecting xylem and phloem differentiation.

ILC3s select for RORγt+ Tregs and establish tolerance to intestinal microbiota

This study identifies ILC3s as key regulators that promote RORγt+ Tregs and suppress Th17 cells to maintain intestinal tolerance to microbiota.

Dissecting the landscape of activated CMV-stimulated CD4+ T cells in human by linking single-cell RNA-seq with T-cell receptor sequencing

This study uses single-cell RNA-seq and TCR sequencing to analyze CMV-reactivated CD4+ T cell subsets, revealing their heterogeneity, functional roles, and interactions.

PulseDIA: in-depth data independent acquisition mass spectrometry using enhanced gas phase fractionation

PulseDIA improves DIA-MS specificity and sensitivity by using gas phase fractionation, achieving higher protein identification rates in cancer proteomics.