S. Dhar

Cell-specific nanoengineering strategy disrupts tolerogenic signaling from myeloid-derived suppressor cells to invigorate antitumor immunity in pancreatic cancer

The paper develops CXCR2-homing nanoparticles to specifically target PMN-MDSCs in PDAC, reducing arginase activity and enhancing T-cell activity without causing neutropenia.

The molecular framework underlying the growth and defense tradeoff in Arabidopsis roots in response to danger signals

This study investigates how PEP1 danger signals affect root meristem development in Arabidopsis by analyzing gene expression changes and identifying STZ as a key regulator of growth-defense tradeoffs.

Experimental type 1 diabetes metabolically rejuvenates CD8+ T cells for improved control of tumor growth through an IGF1-IGF1R axis

This study shows that experimental type 1 diabetes enhances CD8+ T cell function via the IGF1-IGF1R axis, leading to better tumor control.

Nuclear compression-mediated DNA damage drives ATR-dependent Lamin expression and mouse ESC differentiation

The paper shows that nuclear compression-induced DNA damage drives mESC differentiation via ATR-dependent Lamin A/C regulation.

ACKR3 Proximity Labeling Identifies Novel G protein- and β-arrestin-independent GPCR Interacting Proteins

The paper identifies novel GPCR interacting proteins independent of G proteins and β-arrestins using proximity labeling in cells lacking β-arrestin.

DNA Repair Function Scores for 2172 Variants in the BRCA1 Amino-Terminus

The paper presents functional scores for 2172 BRCA1 variants using a multiplexed HDR assay, showing 93% sensitivity and 100% specificity in classifying pathogenic and benign variants.

Novel CAF-identifiers via transcriptomic analysis in oral cancer patients

The paper identifies novel CAF markers in oral cancer through transcriptomic analysis to distinguish CAFs from other cell types.

The repertoire of serous ovarian cancer non-genetic heterogeneity revealed by single-cell sequencing of normal fallopian tube epithelial cells

The paper uses single-cell sequencing to identify non-genetic heterogeneity in serous ovarian cancer by analyzing normal fallopian tube epithelial cells and their subtype signatures.

Role of Physicochemical Properties of Protein in Modulating the Nanoparticle-Bio interface

This study investigates how protein physicochemical properties influence nanoparticle-bio interface formation and cell internalization.

Quantitative Estimation of Long-Range Interactions at the Nanoscale

This study develops a framework to estimate surface tension components of nanoparticles and biomacromolecules, revealing the deterministic role of long-range interactions in biological phenomena.