Author

C. J. Lengner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Cell Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 5 Research Focus:cell type annotation· 4 Organism:mouse· 4 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:clustering· 2

Frequent Co-Authors

N. Li· 4 shared Y. Tian· 4 shared Z. Cramer· 4 shared B. Z. Stanger· 3 shared M. S. Kim· 3 shared S. Adams-Tzivelekidis· 3 shared X. Wang· 3 shared A. Thomas-Tikhonenko· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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4 shared papersCancer Biology

N. Li

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Forward genetic screening in engineered colorectal cancer organoids identifies novel regulators of metastasis

Z. Cramer, X. Wang, N. A. Leu, K. Monaghan, J. H. Rhoades, Y. Tian, J. Rico, D. Mendez, R. Petroni, M. S. Kim, R. Matsuda, M. F. Carrera, I. E. Brodsky, N. Li, C. J. Lengner, M. A. Blanco

The paper uses CRISPR/Cas9 screening in colorectal cancer organoids to identify novel metastasis regulators, finding Ctnna1 and Bcl2l13 as metastasis suppressors.

bioRxiv · Aug 3, 2023 · PreprintCancer Biology

Mapping and modeling human colorectal carcinoma interactions with the tumor microenvironment

N. Li, Q. Zhu, Y. Tian, K. J. Ahn, X. Wang, Z. Cramer, I. W. Folkert, P. Yu, J. Jou, S. Adams-Tzivelekidis, P. Sehgal, N. N. Mahmoud, C. B. Aarons, R. E. Roses, A. Thomas-Tikhonenko, , C. J. Lengner

This study maps and models human colorectal carcinoma interactions with the tumor microenvironment using single-cell transcriptomics and tumoroid cultures, showing how tumoroids suppress inflammation and reprogram macrophages.

bioRxiv · Sep 13, 2022Cancer Biology

Autophagic state prospectively identifies facultative stem cells in the intestinal epithelium

N. M. Johnson, L. R. Parham, J. Na, K. E. Monaghan, H. M. Kolev, A. Klochkova, M. S. Kim, C. H. Danan, Z. Cramer, L. A. Simon, K. E. Naughton, S. Adams-Tzivelekidis, Y. Tian, P. A. Williams, N. A. Leu, , K. E. Hamilton

The paper identifies autophagic state as a marker for facultative stem cells in the intestinal epithelium, independent of lineage or cell age.

bioRxiv · Apr 8, 2022Cell Biology

Patient induced pluripotent stem cell-derived hepatostellate organoids establish a basis for liver pathologies in telomeropathies

Y. Choi, M. S. Kim, J. H. Rhoades, N. M. Johnson, C. T. Berry, S. Root, Q. Chen, Y. Tian, R. J. Fernandez, Z. Cramer, S. Adams-Tzivelekidis, N. Li, F. B. Johnson, C. J. Lengner

The paper uses patient-derived iPS cells to model liver pathologies in telomeropathies and identifies AKT suppression as a potential therapeutic target.

bioRxiv · Nov 19, 2021Cell Biology

MYC hyperactivates WNT signaling in APC/CTNNB1-mutated colorectal cancer cells through miR-92a-dependent repression of DKK3

P. Sehgal, C. Lanauze, X. Wang, K. E. Hayer, M. Torres-Diz, Y. Sela, B. Z. Stanger, C. J. Lengner, A. Thomas-Tikhonenko

This study shows MYC enhances WNT signaling in colorectal cancer cells by repressing DKK3 via miR-92a, creating an oncogenic feedback loop.

bioRxiv · Jul 26, 2021Cancer Biology

GSK3 inhibition rescues growth and telomere dysfunction in dyskeratosis congenita iPSC-derived type II alveolar epithelial cells

R. J. Fernandez, Z. J. G. Gardner, K. J. Slovik, D. C. Liberti, K. N. Estep, W. Yang, Q. Chen, G. T. Santini, J. V. Perez, S. Root, R. Bhatia, J. W. Tobias, A. Babu, M. P. Morley, D. B. Frank, , F. B. Johnson

This study shows that GSK3 inhibition improves growth and telomere function in DC patient-derived AT2 cells by enhancing Wnt signaling.

bioRxiv · Oct 28, 2020Cell Biology

Single-cell lineage and transcriptome reconstruction of metastatic cancer reveals selection of aggressive hybrid EMT states

K. P. Simeonov, C. N. Byrns, M. L. Clark, R. J. Norgard, B. Martin, B. Z. Stanger, A. McKenna, J. Shendure, C. J. Lengner

This study uses macsGESTALT to trace metastatic cancer lineage and transcriptomes, revealing that late-hybrid EMT states drive metastasis and are linked to poor survival in human pancreatic cancer.

bioRxiv · Aug 11, 2020Cancer Biology