P. Yu

Evolutionary trajectory of TRPM2 channel activation by adenosine diphosphate ribose and calcium

The paper traces the evolutionary changes in TRPM2 channel activation mechanisms across species, identifying key stages in the transition from simple to complex ligand binding and calcium gating.

Large-scale multi-omics analyses identified root-microbiome associations underlying plant nitrogen nutrition

The paper identifies root-microbiome associations affecting plant nitrogen nutrition through multi-omics analyses of 1,341 rapeseed samples.

Species- and strain-effects in interferon, innate immunity, and barrier transcriptional response of microbiome interactions of 3D respiratory epithelial cultures

The paper examines how different microbes affect host immune and barrier responses in respiratory epithelial cultures, finding that interferon variability is not linked to microbial diversity or other innate pathways.

Surrogate selection oversamples expanded T cell clonotypes

The paper develops a model to quantify how surrogate selection assays may enrich for amplified T cell clones and explores its implications for immunological data analysis.

Single-Cell Phylogenetic Tracing Maps the Landscape of Human Tumor Immune Cell Plasticity Driven by Microenvironment Factors-Mediated Epigenetic Reprogramming

This study maps immune cell plasticity in human tumors using lineage tracing and reveals microenvironment-driven epigenetic reprogramming as a key mechanism.

Spatiotemporally organized immunomodulatory response to SARS-CoV-2 virus in primary human broncho-alveolar epithelia

This study examines the spatiotemporal immune response to SARS-CoV-2 in human broncho-alveolar epithelia, finding variant-specific kinetics and spatially organized gene expression patterns.

TERT accelerates BRAF mutant-induced thyroid cancer dedifferentiation and progression by regulating ribosome biogenesis

This study shows TERT promotes thyroid cancer dedifferentiation and progression by enhancing ribosome biogenesis, and inhibiting rRNA synthesis can reverse this process.

Evaluation of antibody kinetics and durability in health subjects vaccinated with inactivated COVID-19 vaccine (CoronaVac): A cross-sectional and cohort study in Zhejiang, China

This study evaluates antibody kinetics and durability after CoronaVac vaccination in health subjects, finding waning antibody levels over time and improved responses with a booster dose.

Global mosquito virome profiling and mosquito spatial diffusion pathways revealed by marker-viruses

The paper profiles global mosquito viromes across species, locations, and climates, identifies core-viruses, and links viral diversity to ecological factors and mosquito movement.

Structural insights into the elevator-type transport mechanism of a bacterial ZIP metal transporter

This study determines the structural mechanism of a bacterial ZIP metal transporter, revealing an elevator-type transport mechanism through structural and computational analysis.

Mapping and modeling human colorectal carcinoma interactions with the tumor microenvironment

This study maps and models human colorectal carcinoma interactions with the tumor microenvironment using single-cell transcriptomics and tumoroid cultures, showing how tumoroids suppress inflammation and reprogram macrophages.

Spatiotemporal landscape of SARS-CoV-2 pulmonary infection reveals Slamf9+Spp1+ macrophages promoting viral clearance and inflammation resolution

This study identifies Slamf9+Spp1+ macrophages in hamsters that promote SARS-CoV-2 clearance and inflammation resolution through spatial transcriptomics and scRNA-seq.

Dynamic Landscapes of tRNA Transcriptomes and Translatomes in Diverse Mouse Tissues

This study examines tRNA transcriptomes and translatomes in mouse tissues to explore their relationship with translational efficiency and tissue-specific proteomes.

Comparative transcriptomics and metabolomics reveal specialized metabolite drought stress responses in switchgrass (Panicum virgatum L.)

This study compares transcriptomic and metabolomic responses to drought in two switchgrass genotypes, identifying specialized diterpenoids as key to drought tolerance.

CoVac501, a self-adjuvanting peptide vaccine conjugated with TLR7 agonists, against SARS-CoV-2 induces protective immunity

CoVac501, a self-adjuvanting peptide vaccine with TLR7 agonists, induces strong neutralizing antibodies and T cell responses in non-human primates against SARS-CoV-2.

Control of Leaf Width by the APC/CTAD1-WL1-NAL1 Pathway in Rice

This study identifies the APC/CTAD1-WL1-NAL1 pathway as a regulator of leaf width in rice and shows that mutations in WL1 lead to leaf width variation.

Alkaliphilus flagellata sp. nov., Butyricicoccus intestinisimiae sp. nov., Clostridium mobile sp. nov., Clostridium simiarum sp. nov., Dysosmobacter acutus sp. nov., Paenibacillus brevis sp. nov., Peptoniphilus ovalis sp. nov., and Tissierella simiarum sp. nov., isolated from monkey feces

The paper describes eight novel bacterial species isolated from cynomolgus monkey feces and provides their taxonomic characterization.

Constitutive expression of JASMONATE RESISTANT 1 elevates content of several jasmonates and primes Arabidopsis thaliana to better withstand drought

Constitutive expression of JAR1 primes Arabidopsis thaliana to better withstand drought stress by increasing JA-Ile content and altering adaptive systems.

Dynamic surveillance of mosquitoes and their viromes in Wuhan during 2020.

This study analyzes mosquito species and viromes in Wuhan, China, from April to October 2020, revealing seasonal changes and stable viruses in Culex mosquitoes.

Precision Genome and Base Editing by Regulating mRNA Nuclear Export Using Selective Inhibitors of Nuclear Export

This study identifies SINEs as inhibitors of CRISPR-Cas9 activity by blocking Cas9 mRNA nuclear export, enhancing genome and base editing specificity in human cells.

Spike Protein Targeting "Nano-Glue" that Captures and Promotes SARS-CoV-2 Elimination

This paper discovers CIPS nanosheets that selectively bind SARS-CoV-2 spike protein, inhibit viral entry, and promote macrophage-mediated viral elimination.

Effects of active dry yeast on growth performance, rumen fermentation characteristics and slaughter performance in beef cattle

This study examines how adding active dry yeast to the diet of beef cattle affects their growth, rumen fermentation, and slaughter performance, finding that 4 g/head/d improves microbial composition and carcass weight compared to low nutrition.

Adsorption mechanism of bacteria onto a Na-montmorillonite surface with organic and inorganic calcium

This study compares the adsorption of bacteria onto Na-montmorillonite using organic and inorganic calcium sources, finding organic calcium forms denser aggregates and is more environmentally friendly.

Recombinant SARS-CoV-2 RBD molecule with a T helper epitope as a built in adjuvant induces strong neutralization antibody response

This study develops a recombinant SARS-CoV-2 RBD molecule fused with a T helper epitope as an adjuvant, showing strong neutralizing antibody response in mice.

FGFR Signaling Coordinates the Balance Between Glycolysis and Fatty Acid β-Oxidation in Lymphatic Endothelial Cells

This study shows FGFR signaling regulates the balance between glycolysis and fatty acid β-oxidation in lymphatic endothelial cells, with FGFR inhibition increasing FAO and impairing cell proliferation.

CREB1 contributes colorectal cancer cell plasticity by regulating lncRNA CCAT1 and NF-κB pathways

This study shows that CREB1 regulates colorectal cancer cell plasticity by controlling lncRNA CCAT1 and the NF-κB pathway through interactions with CBP/p300 and p65.

Lack of Reinfection in Rhesus Macaques Infected with SARS-CoV-2

This study shows that rhesus macaques infected with SARS-CoV-2 are protected from reinfection during early recovery, likely due to enhanced neutralizing antibodies.

Ocular conjunctival inoculation of SARS-CoV-2 can cause mild COVID-19 in Rhesus macaques

This study shows that SARS-CoV-2 can cause mild COVID-19 in rhesus macaques through conjunctival inoculation, with distinct viral dispersion patterns compared to intratracheal inoculation.

The Pathogenicity of SARS-CoV-2 in hACE2 Transgenic Mice

This study infects hACE2 transgenic mice with SARS-CoV-2 and observes pathogenic effects, confirming Koch's postulates and establishing a model for vaccine and therapeutic development.

Root type and soil phosphate determine the taxonomic landscape of colonizing fungi and the transcriptome of field-grown maize roots

The paper shows that maize root type and soil phosphate levels shape fungal communities and root transcriptomes, with lateral roots showing specific defense responses and reduced arbuscular mycorrhiza colonization at high phosphate.