TGFβ signalling is required to maintain pluripotency of human naïve pluripotent stem cells
A. Osnato, S. Brown, C. Krueger, S. Andrews, A. J. Collier, S. Nakanoh, M. Quiroga Londono, B. T. Wesley, D. Muraro, S. Brumm, K. Niakan, L. Vallier, D. Ortmann, P. J. Rugg-Gunn
This study shows that TGFβ signalling maintains naive human pluripotency by regulating SMAD2/3 binding and gene expression, with distinct effects compared to primed hPSCs.
bioRxiv · Jul 10, 2021Cell Biology