C. L. Sawyers

This study identifies NSD2 as a key driver of lineage plasticity and castration-resistance in neuroendocrine prostate cancer, showing its inhibition can restore sensitivity to AR inhibitors.

This paper introduces a mouse model of rectal cancer that mimics human tumor progression and radiation response for preclinical studies.

The paper identifies stem-like luminal cells with elevated JAK/STAT signaling as a source of multilineage plasticity in prostate cancer, offering a therapeutic target.

This study develops a rectal cancer organoid model that mimics patient tumor responses to chemoradiation and metastasis in mice.

This study identifies GREB1 as a driver of antiandrogen resistance in prostate cancer by amplifying androgen receptor output through enhanced DNA binding and p300 recruitment.