Author

J. J. Smith

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Biochemistry· 2 Evolutionary Biology· 2 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell type annotation· 3 Organism:mouse· 3 Research Focus:development & morphogenesis· 2 Approach:genetic perturbation / CRISPR· 2 Assay:organoid / primary culture· 2

Frequent Co-Authors

C. Wu· 3 shared C. L. Sawyers· 2 shared C.-T. Chen· 2 shared J. Garcia-Aguilar· 2 shared J. Shia· 2 shared P. B. Paty· 2 shared P. B. Romesser· 2 shared S. W. Lowe· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

C. Wu

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Author profile →

8 papers

Recent·Most cited

A genetically-encoded fluorescent biosensor for visualization of acetyl-CoA in live cells

J. J. Smith, T. R. Valentino, A. H. Ablicki, R. Banerjee, A. R. Colligan, D. M. Eckert, G. A. Desjardins, K. L. Diehl

This paper develops a genetically-encoded fluorescent biosensor to measure acetyl-CoA in live cells, showing its utility in E. coli and HeLa cells for detecting acetyl-CoA dynamics and compartmentalization.

bioRxiv · Dec 31, 2023Biochemistry

Cytoplasmic Male Sterility and Abortive Seed Traits Generated through Mitochondrial Genome Editing Coupled with Allotopic Expression of atp1 in Tobacco

R. E. Dewey, D. Selote, H. C. Griffin, A. N. Dickey, D. Jantz, J. J. Smith, A. Matthiadis, J. Strable, C. Kestell, W. A. Smith

This paper demonstrates that allotopic expression of mitochondrial atp1 in tobacco, combined with genome editing to eliminate the endogenous gene, generates cytoplasmic male sterility and abortive seed traits.

bioRxiv · Jun 12, 2023 · PreprintPlant Biology

Structural basis and functional roles for Toll-like receptor binding to Latrophilin adhesion-GPCR in embryo development

G. Carmona-Rosas, J. Li, J. J. Smith, S. Cheng, E. Baltrusaitis, W. I. Nawrocka, M. Zhao, P. Kratsios, D. Arac, E. Özkan

This study identifies TOL-1 as a ligand for LAT-1 in C. elegans, showing their interaction is essential for embryonic development.

bioRxiv · May 4, 2023 · PreprintBiochemistry

Mediator Kinase Inhibition Impedes Transcriptional Plasticity and Prevents Resistance to ERK/MAPK-Targeted Therapy in KRAS-Mutant Cancers

D. P. Nussbaum, C. A. Martz, A. M. Waters, A. Barrera, J. C. Rutter, C. G. Cerda-Smith, A. E. Stewart, C. Wu, M. Cakir, C. B. Levandowski, D. E. Kantrowitz, S. J. McCall, M. Pierobon, E. Petricoin, J. J. Smith, , K. C. Wood

This study shows that Mediator kinase inhibition prevents resistance to ERK/MAPK inhibitors in KRAS-mutant cancers by blocking transcriptional plasticity.

bioRxiv · Sep 17, 2022 · PreprintCancer Biology

Reconstructing the ancestral vertebrate brain using a lamprey neural cell type atlas

F. Lamanna, F. Hervas-Sotomayor, A. P. Oel, D. Jandzik, D. Sobrido-Camean, M. L. Martik, S. A. Green, T. Brüning, K. Mössinger, J. Schmidt, C. Schneider, M. Sepp, F. Murat, J. J. Smith, M. E. Bronner, , H. Kaessmann

This study reconstructs the ancestral vertebrate brain by comparing a lamprey neural cell type atlas with data from jawed vertebrates, identifying shared features and evolutionary novelties.

bioRxiv · Feb 28, 2022 · PreprintEvolutionary Biology

A new immunocompetent rectal cancer model to study radiation therapy

J. K. Kim, C. Wu, M. Del Latto, Y. Gao, S.-H. Choi, M. Kierstead, C.-E. G. Sauve, C. Firat, A. C. Perez, J. Sillanpaa, C.-T. Chen, K. E. Lawrence, P. B. Paty, F. M. Barriga, J. Shia, , J. J. Smith

This paper introduces a mouse model of rectal cancer that mimics human tumor progression and radiation response for preclinical studies.

bioRxiv · Feb 7, 2022 · PreprintCancer Biology

The genomics of trait combinations and their influence on adaptive divergence

M. B. Calvert, M. M. Doellman, J. L. Feder, G. R. Hood, P. Meyers, S. P. Egan, T. H. Q. Powell, M. Glover, C. Tait, H. Schuler, S. Berlocher, J. J. Smith, P. Nosil, D. A. Hahn, G. J. Ragland

The paper investigates how genetic correlations between traits influence adaptive divergence in apple maggot flies, showing that antagonistic pleiotropy shapes genomic footprints of rapid adaptation.

bioRxiv · Jun 19, 2020 · PreprintEvolutionary Biology

A rectal cancer model establishes a platform to study individual responses to chemoradiation

K. Ganesh, C. Wu, K. P. O'Rourke, M. Adileh, B. C. Szeglin, I. Wasserman, M. R. Marco, M. Shady, Y. Zheng, W. R. Karthaus, H. H. Won, S.-H. Choi, R. A. Pelossof, A. Barlas, E. Pappou, , J. J. Smith

This study develops a rectal cancer organoid model that mimics patient tumor responses to chemoradiation and metastasis in mice.

bioRxiv · May 22, 2019 · PreprintCancer Biology