C. M. Crump

The paper identifies MAT2A as a critical host factor for BKPyV infection through a CRISPR/Cas9 screen and shows a small molecule inhibitor of MAT2A is a potent antiviral drug.

This paper shows HSV-1 protein pUL21 activates CERT to increase ceramide to sphingomyelin conversion, but does not affect virus replication or spread.

This study uses cryo-soft-X-ray tomography to image HSV-1 infected cells in near-native state, revealing morphological changes in organelles like mitochondria and cytoplasmic vesicles.

This study identifies pUL21 as a viral phosphatase adaptor that promotes HSV-1 replication and spread by directing dephosphorylation and antagonizing pUS3 kinase activity.

This study uses a recombinant reporter virus to analyze the spatiotemporal dynamics of host cell modifications during herpes simplex virus 1 replication.

This paper solves the structure of the HSV-1 pUL7:pUL51 complex, showing its conservation across herpesviruses and its potential role in membrane remodeling during virus assembly.

This study identifies HSV-1 pUL56 as a protein that degrades GOPC, altering the plasma membrane proteome by affecting signaling receptors.