Cell BiologybioRxiv
The ESCRT protein CHMP5 restricts bone formation by controlling endolysosome-mitochondrion-mediated cell senescence
F. Zhang, Y. Wang, L. Zhang…·X. Ge
This study shows that CHMP5 regulates bone formation by controlling endolysosome-mitochondrion-mediated cell senescence, and targeting senescent cells can alleviate musculoskeletal abnormalities.
DOI 10.7554/elife.101984