Author

J. Fox

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Biochemistry· 1 Cancer Biology· 1 Ecology· 1 Microbiology· 1 Scientific Communication & Education· 1

Signature Assays, Organisms & Methods

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Organism:human· 7 Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Assay:proteomics· 3 Approach:statistical model· 3 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

A. Waters· 2 shared C. Graham· 2 shared C. Mant· 2 shared C. Willberg· 2 shared E. Hopkins· 2 shared H. Brown· 2 shared J. Frater· 2 shared J. Meyerowitz· 2 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersImmunology

A. Waters

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Positionally distinct interferon stimulated dermal immune acting fibroblasts promote neutrophil recruitment in Sweet's syndrome

K. J. Cavagnero, J. Albright, F. Li, T. Dokoshi, R. Bogle, J. Kirma, J. M. Kahlenberg, A. C. Billi, J. Fox, A. Coon, C. J. Dobry, B. Hinds, L. C. Tsoi, P. W. Harms, J. E. Gudjonsson, R. L. Gallo

This study identifies interferon-responsive dermal fibroblasts in Sweet's syndrome that promote neutrophil recruitment through chemokine expression and spatial positioning.

bioRxiv · Jun 24, 2024Immunology

Broad and potent neutralizing mAbs are elicited in vaccinated individuals following Delta/BA.1 breakthrough infection

J. Seow, Z. A. Shalim, C. Graham, S. Kimuda, A. Pillai, T. Lechmere, A. Kurshan, A. Khimji, L. Snell, G. Nebbia, C. Mant, A. Waters, J. Fox, M. H. Malim, K. J. Doores

The paper shows that vaccinated individuals develop broad neutralizing mAbs after Delta/BA.1 infection, but these mAbs are less effective against newer variants.

bioRxiv · Mar 30, 2023 · PreprintImmunology

Quantitative analysis of food web dynamics in a low export ecosystem

H. M. McNair, M. G. Meyer, S. J. Lerch, A. E. Maas, B. M. Stephens, J. Fox, K. N. Buck, S. M. Burns, I. Cetinic, M. R. Cohn, C. Durkin, S. M. Gifford, W. Gong, J. R. Graff, B. Jenkins, , T. A. Rynearson

The paper quantifies food web dynamics in a low export ecosystem, finding microbial recycling dominates carbon flow with minimal export due to slow turnover and high detrital background.

bioRxiv · Mar 17, 2023 · PreprintEcology

Bacterial Microbiome and Host Inflammatory Gene Expression in Foreskin Tissue

B. S. Maust, S. Petkov, C. Herrera, C. Feng, B. P. Brown, L. Lebina, D. Opoka, A. Ssemata, N. Pillay, J. Serwanga, P. Seatlholo, P. Namubiru, G. Odoch, S. Mugaba, T. Seiphetlo, , the CHAPS team

The paper analyzes the foreskin microbiome and host gene expression in adolescents from South Africa and Uganda, finding no treatment effect on bacterial communities but inverse correlations between bacterial abundance and inflammatory gene expression.

bioRxiv · Aug 29, 2022Microbiology

Allosteric Inhibition of PTP1B by a Nonpolar Terpenoid

A. J. Friedman, E. T. Liechty, L. D. Kramer, A. Sarkar, J. Fox, M. Shirts

This study identifies amorphadiene as a selective allosteric inhibitor of PTP1B, showing it binds to multiple sites on the C-terminus and stabilizes the PTP1B-AD complex.

bioRxiv · May 18, 2022Biochemistry

ChAdOx1 nCoV-19 (AZD1222) vaccine elicits monoclonal antibodies with potent cross-neutralizing activity against SARS-CoV-2 viral variants

J. Seow, C. Graham, S. R. Hallett, T. Lechmere, T. J. A. Maguire, I. Huettner, D. Cox, R. Roberts, A. Waters, C. C. Ward, C. Mant, M. J. Pitcher, J. Spencer, J. Fox, M. H. Malim, K. J. Doores

This study isolates monoclonal antibodies from a vaccinated individual and shows they neutralize multiple SARS-CoV-2 variants effectively.

bioRxiv · Sep 27, 2021Immunology

Clinical positioning of the IAP antagonist tolinapant (ASTX660) in colorectal cancer

D. B. Longley, N. T. Crawford, K. J. Stott, T. Sessler, C. McCann, W. McDaid, C. Latimer, J. Fox, J. M. Munck, T. Smyth, A. Shah, V. Martins, M. Lawler, P. D. Dunne, E. M. Kerr, , V. M. Coyle

This study shows tolinapant, an IAP inhibitor, enhances chemotherapy-induced apoptosis in colorectal cancer by modulating FLIP and HDACs, suggesting its clinical use in poor prognosis MSS CRC with elevated cIAP1/2.

bioRxiv · Nov 20, 2020Cancer Biology

A data-based guide to the North American ecology faculty job market

J. Fox

The paper analyzes data on 566 ecology faculty hires in North America from 2016 to 2018 to address market trends, gender diversity, and hiring practices.

bioRxiv · Sep 7, 2019Scientific Communication & Education

HIV reservoir size is determined prior to ART initiation and linked to CD8 T cell activation and memory expansion

G. E. Martin, M. Pace, F. Shearer, E. Zilber, J. Hurst, J. Meyerowitz, J. P. Thornhill, J. Lwanga, H. Brown, N. Robinson, E. Hopkins, N. Olejniczak, N. Nwokolo, J. Fox, S. Fidler, , CHERUB investigators

This study finds that pre-ART HIV DNA levels predict reservoir size one year after treatment initiation during primary HIV infection, linked to CD8 T cell activation and memory expansion.

bioRxiv · Mar 17, 2019Immunology

Enrichment of the HIV reservoir in CD32+ CD4 T cells occurs early in blood and tissue

G. Martin, M. Pace, J. Thornhill, C. Phetsouphanh, J. Meyerowitz, M. Gossez, E. Hopkins, H. Brown, N. Robinson, N. Olejniczak, G. Ramjee, P. Kaleebu, K. Porter, C. Willberg, P. Klenerman, , J. Frater

The paper shows HIV DNA enrichment in CD32+ CD4 T cells early in infection but finds no correlation with rebound viraemia or HIV DNA levels.

bioRxiv · Jul 27, 2017Immunology