A deep lung cell atlas reveals cytokine-mediated lineage switching of a rare cell progenitor of the human airway epithelium
A. Waghray, I. Monga, B. Lin, V. Shah, M. Slyper, B. Giotti, J. Xu, J. Waldman, D. Dionne, L. T. Nguyen, W. Lou, P. Cai, E. Park, C. Muus, J. Sun, , J. Rajagopal
This study identifies a rare progenitor cell population in the human airway that can differentiate into ionocytes or tuft cells, and shows cytokines can shift their lineage towards tuft cells in asthma and CF.
bioRxiv · Nov 28, 2023 · PreprintCell Biology