Airway basal stem cells are necessary for the maintenance of functional intraepithelial airway macrophages.
T. Kooistra, B. Saez, M. Roche, A. Egea-Zorrilla, D. Li, D. Anketell, N. Nguyen, J. Villoria, J. Gillis, E. Petri, L. Vera, N. P. Smith, J. Alladina, Y. Zhang, V. Vinarsky, , A. Pardo-Saganta
This study shows that airway basal stem cells maintain intraepithelial airway macrophages via Notch signaling, enabling localized allergic inflammation in the trachea but not distal lung tissues.
bioRxiv · Jun 25, 2024Cell Biology