Author

J. Rajagopal

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 5 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 6 Research Focus:cell type annotation· 5 Approach:experimental assay· 4 Assay:proteomics· 3 Research Focus:cell-cell communication· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

B. Lin· 3 shared A. J. Crossen· 2 shared A. Waghray· 2 shared J. L. Reedy· 2 shared J. M. Vyas· 2 shared J. Xu· 2 shared M. V. Surve· 2 shared V. Shah· 2 shared

Activity by Year

2022-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersCell Biology

B. Lin

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Airway basal stem cells are necessary for the maintenance of functional intraepithelial airway macrophages.

T. Kooistra, B. Saez, M. Roche, A. Egea-Zorrilla, D. Li, D. Anketell, N. Nguyen, J. Villoria, J. Gillis, E. Petri, L. Vera, N. P. Smith, J. Alladina, Y. Zhang, V. Vinarsky, , A. Pardo-Saganta

This study shows that airway basal stem cells maintain intraepithelial airway macrophages via Notch signaling, enabling localized allergic inflammation in the trachea but not distal lung tissues.

bioRxiv · Jun 25, 2024Cell Biology

A deep lung cell atlas reveals cytokine-mediated lineage switching of a rare cell progenitor of the human airway epithelium

A. Waghray, I. Monga, B. Lin, V. Shah, M. Slyper, B. Giotti, J. Xu, J. Waldman, D. Dionne, L. T. Nguyen, W. Lou, P. Cai, E. Park, C. Muus, J. Sun, , J. Rajagopal

This study identifies a rare progenitor cell population in the human airway that can differentiate into ionocytes or tuft cells, and shows cytokines can shift their lineage towards tuft cells in asthma and CF.

bioRxiv · Nov 28, 2023 · PreprintCell Biology

Single Cell Transcriptomes, Lineage, and Differentiation of Functional Airway Microfold Cells

M. V. Surve, B. Lin, J. L. Reedy, A. J. Crossen, A. Xu, B. S. Klein, J. M. Vyas, J. Rajagopal

This study identifies and characterizes airway Microfold (M) cells using single-cell transcriptomics, revealing their lineage, differentiation pathways, and functional role in antigen sampling via CR2-dependent endocytosis.

bioRxiv · Aug 6, 2023Cell Biology

Fungal melanin suppresses airway epithelial chemokine secretion through blockade of calcium fluxing

J. L. Reedy, K. N. Jensen, A. J. Crossen, K. J. Basham, R. A. Ward, C. M. Reardon, H. B. Harding, O. W. Hepworth, P. Simaku, G. N. Kwaku, K. Tone, J. A. Willment, D. M. Reid, M. H. Stappers, G. D. Brown, , J. M. Vyas

This study shows fungal melanin blocks chemokine secretion and calcium fluxing in airway epithelial cells, reducing neutrophil recruitment to the airway.

bioRxiv · Mar 28, 2023 · PreprintImmunology

Label free autofluorescence imaging permits comprehensive and simultaneous assignment of cell type identity and reveals the existence of airway secretory cell associated antigen passages (SAPs).

V. Shah, J. Hou, V. Vinarsky, J. Xu, C. P. Lin, J. Rajagopal

This paper introduces a label-free imaging technique using autofluorescence to identify airway cell types and discovers dynamic secretory cell-associated antigen passages.

bioRxiv · Nov 1, 2022Cell Biology

A quiescent resident progenitor pool is the central organizer of tendon healing

M. Grinstein, S. Tsai, D. Montoro, H. Dingwall, K. Zou, M. Sade-Feldman, M. Tanaka, T. D. Capellini, J. Rajagopal, J. L. Galloway

This study identifies Axin2+ tenocytes as quiescent progenitors critical for tendon healing, showing they activate and organize repair after injury.

bioRxiv · Feb 2, 2022Cell Biology