C. Oh

Differential chromatin accessibility and transcriptional dynamics define breast cancer subtypes and their lineages

This study identifies breast cancer subtypes and their lineage origins by analyzing chromatin accessibility and transcriptional dynamics using multi-omic techniques.

Sequence independent activity of a predicted long disordered segment of the human papillomavirus L2 capsid protein during virus entry

The paper shows that the length, not the sequence, of a disordered segment in HPV16 L2 protein determines its activity during virus entry.

Inactivation mechanism and efficacy of grape seed extract for Human Norovirus surrogate

This paper shows grape seed extract (GSE) is more effective than chemical disinfectants at inactivating Tulane virus, a human norovirus surrogate, by causing virus aggregation.

Predicting drug concentrations in PDMS microfluidic organ chips

This paper develops a simulation and experimental method to predict drug concentration profiles in PDMS microfluidic organ chips without prior knowledge of log P or diffusion rates.

Spatial drivers and pre-cancer populations collaborate with the microenvironment in untreated and chemo-resistant pancreatic cancer

This paper uses spatial single-cell omics to analyze PDAC tumors and microenvironment, identifying key populations and interactions that may inform treatment strategies.

Rapid SARS-CoV-2 Detection and Classification Using Phase Imaging with Computational Specificity

This work proposes a rapid (<1 min.), label-free testing method for SARS-CoV-2 detection using quantitative phase imaging and deep learning with 96% accuracy.

Converting Microwave Ovens into Plasma-Generating Decontamination Units for N-95 Respirators

The paper demonstrates a method to decontaminate N-95 respirators using a modified microwave oven, achieving significant viral and bacterial reduction without damaging the respirators.

Patient-derived xenografts undergo murine-specific tumor evolution

This study shows that PDX tumors acquire new genomic changes over passages, differ from human tumors, and affect drug responses.