Author

C. Probst

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 4 Microbiology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:cell type annotation· 6 Organism:human· 4 Research Focus:drug response / drug discovery· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2 Organism:fungi (other)· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

P. Loskill· 3 shared J. A. Alspaugh· 2 shared J. Rogal· 2 shared J. T. Brooks· 2 shared K. Achberger· 2 shared K. Schenke-Layland· 2 shared S. Liebau· 2 shared A. Aufinger· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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3 shared papersBioengineering

P. Loskill

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

JUN mediates senescence and immune cell recruitment to prevent prostate cancer progression

T. Redmer, M. Raigel, C. Sternberg, R. Ziegler, C. Probst, D. Lindner, A. Aufinger, T. Limberger, K. Trachtova, P. Kodajova, S. Hoegler, M. Schlederer, S. Stoiber, M. Oberhuber, M. Bolis, , L. Kenner

This study shows JUN suppresses prostate cancer progression by inducing senescence and immune cell recruitment, with JUN depletion accelerating tumor growth.

bioRxiv · Nov 29, 2023 · PreprintCancer Biology

A fungal lytic polysaccharide monooxygenase is required for cell wall integrity, thermotolerance, and virulence of the fungal human pathogen Cryptococcus neoformans

C. Probst, M. Hallas-Moller, J. O. Ipsen, J. T. Brooks, K. Andersen, M. Haon, J.-G. Berrin, H. J. Martens, C. B. Nichols, K. S. Johansen, J. A. Alspaugh

bioRxiv · Oct 25, 2022 · PreprintMicrobiology

Adaptive changes in the fungal cell wall mediate copper homeostasis

C. Probst, S. Garcia-Santamarina, J. T. Brooks, I. Van Der Kloet, D. J. Thiele, J. A. Alspaugh

This study identifies Cbi1/Bim1 as a copper-binding protein in Cryptococcus neoformans that links copper homeostasis to adaptive changes in the fungal cell wall, including chitin and chitosan levels, and modulates host immune responses.

bioRxiv · Dec 14, 2021 · PreprintMicrobiology

A Tissue-Bioengineering Strategy for Modeling Rare Human Kidney Diseases In Vivo

J. Hernandez, X. Wang, M. Vazquez-Segoviano, M. F. Sobral-Reyes, A. Moran-Horowich, M. Sundberg, M. Lopez-Marfil, D. O. Lopez-Cantu, C. Probst, G. Ruiz-Esparza, K. Giannikou, E. Henske, D. Kwiatkowski, M. Sahin, D. R. Lemos

This paper develops a tissue-bioengineering strategy using TSC patient-derived kidney organoids to model rare kidney diseases in vivo and test therapeutic approaches.

bioRxiv · Oct 20, 2021Bioengineering

Human immunocompetent Choroid-on-Chip: a novel tool for studying ocular effects of biological drugs

M. Cipriano, K. Schluender, C. Probst, K. Linke, M. Weiss, M. J. Fischer, L. Mesch, K. Achberger, S. Liebau, M. Mesquida, V. Nicolini, A. Schneider, A. M. Giusti, S. Kustermann, P. Loskill

The paper develops a human immunocompetent Choroid-on-Chip model to study ocular effects of biological drugs and assess immunotoxicity.

bioRxiv · May 12, 2021Bioengineering

WAT’s up!? – Organ-on-a-chip integrating human mature white adipose tissues for mechanistic research and pharmaceutical applications

J. Rogal, C. Binder, E. Kromidas, C. Probst, S. Schneider, K. Schenke-Layland, P. Loskill

The paper develops a WAT-on-a-chip system to study human white adipose tissue function and drug responses in obesity and diabetes.

bioRxiv · Mar 21, 2019Bioengineering

Human Retina-on-a-Chip: Merging Organoid and Organ-on-a-Chip Technology to Generate Complex Multi-Layer Tissue Models

K. Achberger, C. Probst, J. Haderspeck, S. Bolz, J. Rogal, J. Chuchuy, M. Nikolova, V. Cora, L. Antkowiak, W. Haq, N. Shen, K. Schenke-Layland, M. Ueffing, S. Liebau, P. Loskill

This study develops a retina-on-a-chip model using hiPSC-derived retinal cells to recapitulate retinal interactions and test drug effects.

bioRxiv · Feb 18, 2019Bioengineering