Microenvironment shapes small-cell lung cancer neuroendocrine states and presents therapeutic opportunities
P. A. Desai, N. Takahashi, R. Kumar, S. Nichols, J. Malin, A. Hunt, C. Schultz, Y. Cao, D. Tillo, D. Nousome, L. Chauhan, L. Sciuto, K. Jordan, V. Rajapakse, D. Lissa, , R. El Meskini
This study maps the SCLC tumor microenvironment and identifies cancer-associated fibroblasts as key drivers of neuroendocrine state plasticity and poor prognosis.
bioRxiv · Feb 9, 2024Cancer Biology