Author

D. Chapman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 6 Physiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:mouse· 6 Research Focus:cell signaling & trafficking· 4 Research Focus:cell type annotation· 4 Assay:proteomics· 4 Research Focus:development & morphogenesis· 2 Research Focus:differential expression· 2 Organism:rat· 2

Frequent Co-Authors

J. T. Field· 5 shared M. D. Martens· 5 shared A. R. West· 4 shared J. W. Gordon· 4 shared G. M. Hatch· 3 shared S. Ghavami· 3 shared V. W. Dolinsky· 3 shared Y. Hai· 3 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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5 shared papersCell Biology

J. T. Field

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

The mitophagy receptor BNIP3L/Nix coordinates nuclear calcium signaling to modulate the muscle phenotype.

J. T. Field, D. Chapman, Y. Hai, S. Ghavami, A. R. West, B. Ozerklig, A. Saleem, J. Kline, A. A. Mendelson, J. Kindrachuk, B. Triggs-Raine, J. W. Gordon

This study shows Nix regulates muscle phenotype by coordinating mitophagy, ER-phagy, and nuclear calcium signaling, affecting insulin sensitivity and fiber-type composition.

bioRxiv · Mar 18, 2023 · PreprintCell Biology

Conserved basal lamina proteins, laminin and nidogen, are repurposed to organize mechanosensory complexes responsible for touch sensation.

A. Das, J. A. Franco, B. Mulcahy, L. Wang, D. Chapman, C. Jaisinghani, B. L. Pruitt, M. Zhen, M. B. Goodman

This study shows that laminin and nidogen in the basal lamina form complexes with the MEC-4 channel to enable touch sensation in C. elegans.

bioRxiv · Feb 11, 2022 · PreprintCell Biology

Differential Impact of Doxorubicin Dose on Cell Death and Autophagy Pathways during Acute Cardiotoxicity.

P. Kawalec, M. D. Martens, J. T. Field, W. Mughal, A. M. Caymo, D. Chapman, B. Xiang, S. Ghavami, V. W. Dolinsky, J. Gordon

This study examines the effects of low- and high-dose doxorubicin on cardiac structure, function, and cell death pathways in mice, finding that high-dose DOX causes necrosis and autophagy inhibition, while low-dose activates caspase signaling.

bioRxiv · Jan 15, 2022Physiology

Misoprostol Treatment Prevents Hypoxia-Induced Cardiac Dysfunction Through a 14-3-3 and PKA regulatory motif on Bnip3

M. D. Martens, N. Seshadri, L. Nguyen, D. Chapman, E. S. Hensen, B. Xiang, L. Falk, A. Mendoza, S. Rattan, S. B. Gibson, R. Keijzer, A. D. Saleem, G. M. Hatch, C. A. Doucette, J. M. Karch, , J. W. Gordon

This study shows misoprostol prevents hypoxia-induced cardiac dysfunction by phosphorylating Bnip3, altering its localization and reducing necroinflammation and mitochondrial damage.

bioRxiv · Oct 9, 2020Cell Biology

Misoprostol Attenuates Cardiomyocyte Proliferation in the Neonatal Heart Through Bnip3 and Perinuclear Calcium Signaling

M. D. Martens, J. T. Field, N. Seshadri, C. Day, D. Chapman, R. Keijzer, C. R. Doucette, G. M. Hatch, A. R. West, T. L. Ivanco, J. W. Gordon

This study shows misoprostol reduces neonatal cardiomyocyte proliferation via Bnip3 and calcium signaling, offering potential therapeutic benefits for neonatal heart conditions.

Journal of Molecular and Cellular Cardiology · Sep 1, 2020Peer-reviewedCell Biology

Nix induced mitochondrial fission, mitophagy, and myocyte insulin resistance are abrogated by PKA phosphorylation.

S. C. da Silva Rosa, M. D. Martens, J. T. Field, L. Nguyen, S. Kereliuk, Y. Hai, D. Chapman, W. Diehl-Jones, M. Aliani, A. R. West, J. Thliveris, S. Ghavami, C. Rampitsch, V. W. Dolinsky, J. Gordon

The paper shows that Nix-induced mitochondrial fission, mitophagy, and insulin resistance in myocytes are reversed by PKA phosphorylation.

bioRxiv · Feb 20, 2020Cell Biology

Renewal theory provides a universal quantitative framework to characterise the continuous regeneration of rotational events in cardiac fibrillation

D. Dharmaprani, M. Schopp, P. Kuklik, D. Chapman, A. Lahiri, L. Dykes, F. Xiong, M. Aguilar, B. Strauss, L. Mitchell, K. Pope, C. Meyer, S. Willems, F. G. Akar, S. Nattel, , A. N. Ganesan

The paper applies renewal theory to model phase singularity dynamics in cardiac fibrillation across species, finding exponential inter-event time distributions with consistent rate parameters.

bioRxiv · Apr 4, 2019 · PreprintPhysiology

Misoprostol regulates Bnip3 repression and alternative splicing to control cellular calcium homeostasis during hypoxic stress.

J. T. Field, M. D. Martens, W. Mughal, Y. Hai, D. Chapman, G. M. Hatch, T. L. Ivanco, W. Diehl-Jones, J. W. Gordon

This study shows misoprostol reduces Bnip3 expression and promotes alternative splicing to protect cells from hypoxia-induced damage by regulating calcium homeostasis.

bioRxiv · May 2, 2018Cell Biology