In vivo CRISPR screens reveal Serpinb9 and Adam2 as regulators of immune therapy response in lung cancer
D. Dervovic, E. L. Y. Chen, A. Malik, S. Afiuni, J. Boucher, J. M. Berman, K. Teng, A. Ayyaz, Y. Lu, M. Narimatsu, G. Mbamalu, S. Loganathan, S. Martinez, R. Tsai, J.-B. Lee, , D. Schramek
The paper uses in vivo CRISPR screens to identify Serpinb9 and Adam2 as genes regulating immune therapy response in lung cancer, showing their roles in immune suppression and enhancement.
bioRxiv · Mar 13, 2022Cancer Biology