Author

D. Dunlap

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 8 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:chromatin & epigenetic regulation· 7 Assay:DNA methylation· 7 Organism:E. coli· 4 Research Focus:cell signaling & trafficking· 3 Organism:bacteria (other)· 2 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

L. Finzi· 8 shared Y. Yan· 4 shared I. Artsimovitch· 3 shared J. Qian· 3 shared W. Xu· 3 shared A. Zhang· 2 shared B. Wang· 2 shared F. Leng· 2 shared

Activity by Year

2021-2023 · peak 6/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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8 shared papersBiophysics

L. Finzi

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Force and the α-C-terminal domains bias RNApolymerase recycling

J. Qian, B. Wang, I. Artsimovitch, D. Dunlap, L. Finzi

The paper investigates how force and α-C-terminal domains influence RNA polymerase recycling after termination, showing force biases diffusion direction and promoter recognition.

bioRxiv · Nov 2, 2023 · PreprintBiophysics

The renal capsule, a vibrant and adaptive cell environment of the kidney in homeostasis and aging

B. Korin, S. Avraham, R. Moncada, T. Ho, M. C. Tleugabulova, H. Menon, S. Darmanis, Y. Liang, Z. Modrusan, C. Chalouni, C. Victoria, L. Rangell, C. Havnar, W. Ewart, C. Jones, , A. S. Shaw

This study characterizes the renal capsule's cellular composition and dynamics in health, aging, and disease, revealing its adaptive responses and age-related changes.

bioRxiv · May 11, 2023 · PreprintImmunology

Reciprocating RNA Polymerase batters throughroadblocks

J. Qian, A. G. Cartee, W. Xu, Y. Yan, B. Wang, I. Artsimovitch, D. Dunlap, L. Finzi

This study investigates how RNA polymerase navigates protein roadblocks in E. coli, showing force-dependent effects and the role of GreA in facilitating passage.

bioRxiv · Jan 4, 2023Biophysics

Transcription disrupts DNA-scaffolded bacteriophage repressor complexes

Y. Lu, Z. Voros, G. Borjas, C. Hendrickson, K. E. Shearwin, D. Dunlap, L. Finzi

The paper shows that DNA-scaffolded bacteriophage repressor complexes do not effectively block transcription by E. coli RNA polymerase.

bioRxiv · Oct 29, 2021 · PreprintBiophysics

A thermodynamic model of bacterial transcription

J. Qian, D. Dunlap, L. Finzi

This paper introduces a thermodynamic model of bacterial transcriptional pausing that predicts pause kinetics and factors like tension and GreA.

bioRxiv · Oct 27, 2021 · PreprintBiophysics

Ionic strength modulates HU protein-induced DNA supercoiling

A. Zhang, Y. Yan, F. Leng, D. Dunlap, L. Finzi

This study investigates how ionic strength affects HU protein-induced DNA supercoiling and compaction using single-molecule techniques.

bioRxiv · Oct 14, 2021 · PreprintBiophysics

Positive supercoiling favors transcription elongation through lac repressor-mediated DNA loops

W. Xu, Y. Yan, I. Artsimovitch, D. Dunlap, L. Finzi

The paper shows that positive supercoiling helps RNA polymerase bypass LacI-mediated DNA loops in E. coli by reducing pauses and enhancing dissociation of roadblocks.

bioRxiv · Mar 2, 2021Biophysics

Negative DNA supercoiling makes protein-mediated looping deterministic and ergodic within the bacterial doubling time

Y. Yan, W. Xu, S. Kumar, A. Zhang, F. Leng, D. Dunlap, L. Finzi

The paper shows that negative DNA supercoiling reduces stochasticity in protein-mediated DNA looping, making it deterministic and ergodic within bacterial doubling time.

bioRxiv · Feb 25, 2021Biophysics

Nanomechanics of negatively supercoiled diaminopurine-substituted DNA

D. Salerno, F. Mantegazza, V. Cassina, M. Cristofalo, Q. Shao, L. Finzi, D. Dunlap

This study investigates how diaminopurine substitution affects DNA conformational dynamics under tension and unwinding, revealing distinct mechanical properties of DAP-substituted DNA.

bioRxiv · Feb 24, 2021Biophysics