Author

A. Buckle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:chromatin & epigenetic regulation· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Organism:chicken / avian· 1

Frequent Co-Authors

C. A. Brackley· 2 shared D. Marenduzzo· 2 shared N. Gilbert· 2 shared A. Bai· 1 shared A. Gupta· 1 shared A. N. Gerber· 1 shared B. T. Riley· 1 shared C. Sacristan· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersCell Biology

C. A. Brackley

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Condensin reorganizes centromeric chromatin during mitotic entry into a bipartite structure stabilized by cohesin

C. Sacristan, K. Samejima, L. Andrade Ruiz, M. L. A. Lambers, A. Buckle, C. A. Brackley, D. Robertson, T. Hori, S. Webb, T. Fukagawa, N. Gilbert, D. Marenduzzo, W. C. Earnshaw, G. J. P. L. Kops

This study shows vertebrate centromeres form a bipartite structure during mitosis, stabilized by condensin and linked by cohesin, which prevents merotelic attachments and chromosomal instability.

bioRxiv · Aug 1, 2022 · PreprintCell Biology

Alpha-1-antitrypsin binds to the glucocorticoid receptor with biological significance in macrophages

X. Bai, A. Bai, M. Tomasicchio, J. Hagman, A. Buckle, A. Gupta, V. Kadiyala, S. Bevers, K. Serban, K. Kim, Z. Feng, K. Spiender, G. Hagen, L. B. Fornis, D. E. Griffith, , E. D. Chan

This study identifies AAT binding to the glucocorticoid receptor in macrophages, showing its role in anti-inflammatory and host-defense functions.

bioRxiv · Mar 11, 2022 · PreprintImmunology

Transcription modulates chromatin dynamics and locus configuration sampling

G. Forte, A. Buckle, S. Boyle, D. Marenduzzo, N. Gilbert, C. A. Brackley

The paper uses simulations and experiments to show transcription affects chromatin dynamics and locus configurations in mouse cells.

bioRxiv · Nov 8, 2021Biophysics

KLK4 inhibition by cyclic and acyclic peptides: structural and dynamical insights into standard-mechanism protease inhibitors

B. T. Riley, O. Ilyichova, S. de Veer, J. swedberg, E. Wilson, D. E. Hoke, J. Harris, A. Buckle

This paper investigates how structural modifications in SFTI-based inhibitors affect their interaction with KLK4, revealing insights into protease inhibition dynamics.

bioRxiv · Mar 8, 2019Biochemistry