RAB7 deficiency impairs pulmonary artery endothelial function and promotes pulmonary hypertension
B. Piper, S. Bogamuwa, T. Hossain, D. Farkas, L. Rosas, A. Green, G. Newcomb, N. Sun, J. C. Horowitz, A. R. Bhagwani, H. Yang, T. V. Kudryashova, M. Rojas, A. L. Mora, P. Yan, , L. Farkas
This study shows RAB7 deficiency impairs endothelial function and causes pulmonary hypertension in mice, with potential for RAB7 activation as a therapeutic strategy.
bioRxiv · Feb 3, 2023Physiology