Author

D. Hayward

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 5 Immunology· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:cell signaling & trafficking· 6 Organism:human· 4 Research Focus:chromatin & epigenetic regulation· 3 Assay:proteomics· 3 Research Focus:development & morphogenesis· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2

Frequent Co-Authors

U. Gruneberg· 5 shared J. Biggs O'May· 3 shared L. de Boer· 3 shared L. Vanes· 3 shared E. Roberts· 2 shared F. A. Barr· 2 shared H. Hartweger· 2 shared R. Koechl· 2 shared

Activity by Year

2019-2022 · peak 6/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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5 shared papersCell Biology

U. Gruneberg

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Angie-LAMP for diagnosis of human eosinophilic meningitis using dog as proxy: A LAMP assay for Angiostrongylus cantonensis DNA in cerebrospinal fluid

V. Balaz, P. Rivory, D. Hayward, S. Jaensch, R. Malik, R. Lee, D. Modry, J. Slapeta

This paper develops a LAMP assay (Angie-LAMP) for detecting Angiostrongylus cantonensis DNA in canine cerebrospinal fluid, showing comparable sensitivity to qPCR and improved portability for field use.

bioRxiv · Dec 19, 2022 · PreprintMicrobiology

Regulated Degradation of the Inner Nuclear Membrane Protein SUN2 Maintains Nuclear Envelope Architecture and Function

L. Krshnan, W. S. Siu, M. Van de Weijer, D. Hayward, E. N. Guerrero, U. Gruneberg, P. Carvalho

This study identifies a degradation mechanism for SUN2, an inner nuclear membrane protein, showing that its regulated turnover is essential for maintaining nuclear envelope structure and function.

bioRxiv · Jul 15, 2022Cell Biology

PP6 regulation of Aurora A-TPX2 limits NDC80 phosphorylation and mitotic spindle size

T. Sobajima, K. Kowalczyk, S. Skylakakis, D. Hayward, L. J. Fulcher, C. Neary, C. Batley, S. Kurlekar, E. Roberts, U. Gruneberg, F. A. Barr

The paper shows that PP6 regulates Aurora A-TPX2 to control NDC80 phosphorylation and mitotic spindle size, preventing defective nuclear structure.

bioRxiv · May 23, 2022Cell Biology

MPS1 localizes to microtubule-attached kinetochores and actively promotesmicrotubule release

D. Hayward, E. Roberts, U. Gruneberg

The paper shows MPS1 localizes to microtubule-attached kinetochores and actively promotes microtubule release, challenging the model of MPS1 as a passive sensor.

bioRxiv · May 23, 2022 · PreprintCell Biology

WNK1-dependent water influx is required for CD4+ T cell activation and T cell-dependent antibody responses

J. Biggs O'May, L. Vanes, L. de Boer, H. Hartweger, S. Kunzelmann, D. Hayward, M. Llorian, D. A. Lewis, R. Koechl, V. Tybulewicz

This study shows that WNK1-dependent water influx is essential for CD4+ T cell proliferation and T cell-dependent antibody responses.

bioRxiv · Mar 16, 2022Immunology

T cell migration requires ion and water influx to regulate actin polymerization

L. de Boer, L. Vanes, S. Melgrati, J. Biggs O'May, D. Hayward, P. Driscoll, J. Day, A. Griffiths, R. Magueta, A. Morrell, J. I. MacRae, R. Koechl, V. Tybulewicz

This study shows that chemokine-induced T cell migration requires water entry at the leading edge to facilitate actin polymerization.

bioRxiv · Mar 16, 2022Immunology

B cell-intrinsic requirement for WNK1 kinase in T cell-dependent antibody responses

D. Hayward, L. Vanes, S. Wissmann, S. Sivapatham, H. Hartweger, J. Biggs O'May, L. De Boer, R. Mitter, R. Kochl, J. V. Stein, V. L. Tybulewicz

This study identifies WNK1 kinase as essential for T-dependent antibody responses by regulating B cell migration, adhesion, and activation.

bioRxiv · Sep 9, 2021 · PreprintImmunology

The C-terminal helix of BubR1 is essential for CENP-E-dependent chromosome alignment

T. Legal, D. Hayward, A. Gluszek-Kustusz, E. BLACKBURN, C. Spanos, J. Rappsilber, U. Gruneberg, J. P. Welburn

This study identifies the molecular interaction between BubR1 and CENP-E required for CENP-E recruitment to kinetochores and chromosome alignment during mitosis.

bioRxiv · Feb 25, 2020Cell Biology

Checkpoint signaling and error correction require regulation of the MPS1 T-loop by PP2A-B56

U. Gruneberg, D. Hayward, J. Bancroft, D. Mangat, T. Alfonso-Perez, S. Dugdale, J. McCarthy, F. A. Barr

The paper shows that PP2A-B56 regulates MPS1 T-loop autophosphorylation, controlling MPS1 activity and mitotic progression.

bioRxiv · May 3, 2019Cell Biology