Author

D. Irimia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Immunology· 3 Biophysics· 1

Signature Assays, Organisms & Methods

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Organism:human· 7 Research Focus:cell signaling & trafficking· 6 Approach:experimental assay· 6 Research Focus:cell type annotation· 3 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Approach:statistical model· 2 Assay:ChIP-seq· 1

Frequent Co-Authors

F. Ellett· 4 shared A. Hopke· 3 shared A. Amir· 2 shared A. Hadjitheodorou· 2 shared G. R. R. Bell· 2 shared J. A. Theriot· 2 shared M. K. Mansour· 2 shared S. R. Collins· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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4 shared papersCell Biology

F. Ellett

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Self-extinguishing relay waves enable homeostaticcontrol of human neutrophil swarming

J. Strickland, D. Pan, C. Godfrey, J. S. Kim, A. Hopke, M. Degrange, B. Villavicencio, M. K. Mansour, C. S. Zerbe, D. Irimia, A. Amir, O. D. Weiner

The paper identifies a self-extinguishing relay wave mechanism in human neutrophils that controls swarming and recruitment levels through an NADPH-oxidase-based feedback loop.

bioRxiv · Jun 27, 2023Cell Biology

Predestined neutrophil heterogeneity in homeostasis varies in transcriptional and phenotypic response to Candida

A. K. Scherer, A. Hopke, S. Xu, A. Viens, N. J. Alexander, K. D. Timmer, D. Archambault, D. Floyd, N. J. Atallah, C. Rhee, M. Cetinbas, D. Scadden, D. Irimia, D. B. Sykes, R. I. Sadreyev, M. K. Mansour

The paper shows that clonal neutrophil progenitors have predestined transcriptional and epigenetic heterogeneity that influences their response to Candida infections.

bioRxiv · Nov 1, 2022 · PreprintImmunology

Mechanical competition promotes selective listening to receptor inputs to resolve directional dilemmas in neutrophil migration

A. Hadjitheodorou, G. R. R. Bell, F. Ellett, D. Irimia, R. Tibshirani, S. R. Collins, J. A. Theriot

This study shows neutrophils resolve directional dilemmas by committing to one leading edge late in the decision process, influenced by mechanical stretching and receptor inputs.

bioRxiv · Feb 21, 2022Cell Biology

Neutrophil Profiles of Pediatric COVID-19 and Multisystem Inflammatory Syndrome in Children

B. P. Boribong, T. J. LaSalle, Y. C. Bartsch, F. Ellett, M. E. Loiselle, J. P. Davis, A. L. K. Gonye, S. Hajizadeh, J. Kreuzer, S. Pillai, W. Haas, A. G. Edlow, A. Fasano, G. Alter, D. Irimia, , L. M. Yonker

The paper identifies neutrophil activation and NET formation in MIS-C linked to SARS-CoV-2 immune complexes, differing from acute pediatric COVID-19.

bioRxiv · Dec 18, 2021Immunology

Directional reorientation of migrating neutrophils is limited by suppression of receptor input signaling at the cell rear through myosin II activity

A. Hadjitheodorou, G. R. R. Bell, F. Ellett, S. Shastry, D. Irimia, S. R. Collins, J. A. Theriot

bioRxiv · Apr 4, 2021Cell Biology

Dynamics of diffusive cell signaling relays

P. Dieterle, J. Min, D. Irimia, A. Amir

This study shows that diffusive signaling relays enable fast-traveling chemical waves, which create steep gradients for cell communication, and demonstrates their relevance in immune response.

bioRxiv · Dec 27, 2019Biophysics

Chemotaxis and swarming in differentiated HL60 neutrophil-like cells

K. A. Babatunde, X. Wang, A. Hopke, P.-Y. Mantel, D. Irimia

This study shows that DMSO-differentiated HL-60 cells exhibit chemotaxis and swarming toward zymosan particles but with less organized movement and smaller swarms compared to primary neutrophils.

bioRxiv · Sep 3, 2019Cell Biology

Megakaryocytes Display Innate Immune Cell Functions and Respond during Sepsis

D. Irimia, G. H. Frydman, F. Ellett, J. Jorgensen, A. L. Marand, L. Zukerberg, M. Selig, S. Tessier, K. H. K. Wong, D. Olaleye, C. R. Vanderburg, J. G. Fox, R. G. Tompkins

This study shows megakaryocytes have innate immune functions and respond during sepsis by chemotaxis, phagocytosis, and chromatin web release.

bioRxiv · Aug 21, 2019 · PreprintImmunology