Author

D. Irvine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Bioengineering· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

A. Hook· 1 shared B. Begines· 1 shared B. Liu· 1 shared C. Tuck· 1 shared D. Draganov· 1 shared D. Lieb· 1 shared E. Janssen· 1 shared E. Prina· 1 shared

Activity by Year

2019-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperBioengineering

A. Hook

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

An efficient lentiviral CRISPRi approach to silence genes in primary human monocytes

B. Liu, N. Hacohen, D. Irvine, M. Gentili, D. Lieb, T. Eisenhaure

This paper develops a lentiviral CRISPRi system to silence genes in primary human monocytes and demonstrates its use in studying gene function.

bioRxiv · Dec 23, 2020 · PreprintImmunology

Ivermectin converts cold tumors hot and synergies with immune checkpoint blockade for treatment of breast cancer

D. Draganov, Z. Han, N. Bennett, D. Irvine, P. P. Lee

This paper shows ivermectin converts cold tumors to hot by inducing immunogenic cancer cell death and enhancing T cell infiltration, synergizing with anti-PD1 to improve breast cancer treatment outcomes.

bioRxiv · Aug 21, 2020Immunology

Inkjet based 3D Printing of bespoke medical devices that resist bacterial biofilm formation

Y. He, B. Begines, J. Luckett, J.-F. Dubern, A. Hook, E. Prina, F. R. Rose, C. Tuck, R. Hague, D. Irvine, P. Williams, M. R. Alexander, R. D. Wildman

This paper develops 3D printing inks that resist bacterial biofilm formation and demonstrate their use in a finger prosthetic to prevent infection.

bioRxiv · Jun 30, 2020 · PreprintBioengineering

Cytoskeletal tension actively sustains the migratory T cell synaptic contact

S. Kumari, M. Mak, Y. Poh, M. Tohme, N. Watson, M. Melo, E. Janssen, M. Dustin, R. Geha, D. Irvine

This study identifies a mechanical mechanism involving cytoskeletal tension that sustains T cell-APC synaptic contact symmetry and stability.

bioRxiv · May 4, 2019Cell Biology