D. Dai

The transcription factor Zeb2 drives differentiation of age-associated B cells

The paper identifies Zeb2 as a critical transcription factor driving age-associated B-cell differentiation and autoimmunity in humans and mice.

Effect of alpha-tubulin acetylation on the doublet microtubule structure

This study examines how alpha-tubulin acetylation affects doublet microtubule structure in Tetrahymena cilia using cryo-EM, MD, and mass spectrometry, finding small-scale structural changes and a link to phosphorylation.

Multi-omics of the gut microbial ecosystem in the immunotherapy resistance in microsatellite instability-high gastrointestinal cancer patients

The paper uses multi-omics data to identify gut microbiome and metabolite markers of immunotherapy resistance in MSI-H/dMMR gastrointestinal cancer patients and develops a predictive model with 0.83 accuracy.

Gut-associated lymphoid tissue attrition associates with response to anti-α4β7 therapy in ulcerative colitis

This study investigates the mechanism of vedolizumab in ulcerative colitis by analyzing immune cell changes in gut-associated lymphoid tissue and shows that targeting GALT is a novel mechanism of action.

Convergent approaches to delineate the metabolic regulation of tumor invasion by hyaluronic acid biosynthesis

This study investigates how hyaluronic acid biosynthesis affects metabolic regulation of tumor invasion in breast cancer cells using integrated experimental and computational approaches.

Towards understanding diversity, endemicity and global change vulnerability of soil fungi

The paper identifies unknown soil fungi using PacBio sequencing and evaluates standardization methods to analyze global diversity, endemicity, and vulnerability patterns.

Chloroplast-localized translation for protein targeting in Chlamydomonas reinhardtii

The paper identifies a chloroplast envelope domain where translation occurs, supporting co-translational protein targeting in Chlamydomonas reinhardtii.

Remodeling and activation mechanisms of outer arm dyneins revealed by cryo-electron microscopy

This study uses cryo-electron microscopy to reveal the structure of outer dynein arms attached to microtubules and proposes a model for their remodeling and activation through molecular dynamics simulations.

The inner junction complex of the cilia is an interaction hub that involves tubulin post-translational modifications

The paper identifies new inner junction proteins in cilia and shows they form an interaction hub involving tubulin post-translational modifications.

Identification and mapping of central pair proteins by proteomic analysis

The paper identifies 37 novel central pair (CP) protein candidates through proteomic analysis of Chlamydomonas mutants and presents a more complete model of CP protein localization.

Tubulin Lattice in Cilia is in a Stressed Form Regulated by Microtubule Inner Proteins

This study presents the near-atomic structure of Tetrahymena doublet microtubules, showing that microtubule inner proteins stabilize the tubulin lattice and contribute to the intrinsic stress in cilia.

Deregulation of TGF-β1 signaling induces glycolysis by chromatin remodeling in pathogenic TH17 cells

This study identifies TGF-β1 signaling's role in chromatin remodeling that drives glycolysis in pathogenic TH17 cells through epigenetic regulation of metabolic regulators.

T-bet+ CD11c+ B Cells Are Critical For Anti-Chromatin IgG Production In The Development Of Lupus