D. Klatzmann

Deciphering Cell-types and Gene Signatures Associated with Disease Activity in Rheumatoid Arthritis using Single Cell RNA-sequencing

This study uses single-cell RNA sequencing of PBMCs from RA patients and controls to identify disease-associated cell subsets and gene signatures linked to RA disease activity.

Tissue-resident uterine regulatory T cells support fetal growth

The paper identifies uterine tissue-resident regulatory T cells (uTregs) that support fetal growth by promoting uterine remodeling and vascular development during pregnancy.

Variability in the local and global composition of human T-cell receptor repertoires during thymic development across cell types and individuals

The paper analyzes human TCR repertoires across thymic development stages and individuals, finding that inter-individual variability persists through maturation and that local sequence similarity correlates with cell type information.

Interleukin-1 regulates follicular T cells during the germinal center reaction

The paper investigates the role of IL-1 receptors in Tfh and Tfr cells during the germinal center reaction, showing that Tfr cell inhibitory receptors prevent their own activation to allow Tfh cell activation.

A thermostable oral SARS-CoV-2 vaccine induces mucosal and protective immunity

This study develops a thermostable oral SARS-CoV-2 vaccine using e-VLPs that induces robust mucosal immunity and complete protection in animal models.

Human thymopoiesis produces polyspecific CD8+ alfa/beta T cells responding to multiple viral antigens

The paper shows human thymopoiesis produces CD8+ T cells with polyspecific TCRs that recognize multiple viral antigens, supporting broad antiviral immunity.

Identification of erythroid cell positive blood transcriptome phenotypes associated with severe respiratory syncytial virus infection

The paper identifies erythroid cell-associated blood transcriptome phenotypes linked to severe RSV infection using meta-analysis of public datasets.

Representativeness and robustness of TCR repertoire diversity assessment by high-throughput sequencing

This study evaluates how sequencing conditions affect TCR repertoire diversity assessment and suggests computational methods to improve accuracy.