Author

M. Giacca

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cell Biology· 2 Microbiology· 2 Pathology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 10 Research Focus:host-pathogen & immune response· 5 Organism:mouse· 5 Assay:bulk RNA-seq· 4 Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:development & morphogenesis· 3 Assay:proteomics· 3

Frequent Co-Authors

E. Schneider· 4 shared L. Braga· 3 shared A. Margariti· 2 shared A. Zampetaki· 2 shared I. Secco· 2 shared L. Zeng· 2 shared S. Zacchigna· 2 shared A. A. M. Elbassioni· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersCancer Biology

E. Schneider

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Tim4 enables large peritoneal macrophages to cross-present tumor antigens at early stages of tumorigenesis

S. Joshi, L. L. Rodriguez, L. G. Morosi, R. Amadio, M. Pachauri, M. Giacca, G. M. Piperno, F. Benvenuti

This study shows TIM4 enables large peritoneal macrophages to cross-present tumor antigens early in tumorigenesis, promoting CD8 T cell activation and immune surveillance.

bioRxiv · Sep 14, 2023Immunology

Tissue-resident uterine regulatory T cells support fetal growth

L. M. Florez, G. Fourcade, G. Darrasse-Jeze, P. Barennes, K. Gan-Fernandez, P. Regnier, D. Nehar-Belaid, T. Courau, M. G. Ruocco, S. Zacchigna, M. Giacca, J. Lion, N. Mooney, N. Tchitchek, E. Mariotti-Ferrandiz, D. Klatzmann

The paper identifies uterine tissue-resident regulatory T cells (uTregs) that support fetal growth by promoting uterine remodeling and vascular development during pregnancy.

bioRxiv · Sep 7, 2023 · PreprintImmunology

Human TUBA1B short open reading frame product regulates cancer cell growth via importin-β

Y. Tao, X. Bai, Y. Zhou, Y. Zhao, L. Yang, S. Zhang, H. Liu, X. Huang, E. Schneider, A. Zampetaki, A. Margariti, M. Giacca, J. N. Arnold, L. Zeng, T. Cai

This study identifies TUBA1B-sORF1, a novel protein from the TUBA1B gene, which promotes cancer cell growth by facilitating nuclear translocation of β-catenin.

bioRxiv · Aug 26, 2023 · PreprintCancer Biology

Human blood vessel organoids reveal a critical role for CTGF in maintaining microvascular integrity

S. G. Romeo, I. Secco, E. Schneider, C. M. Reumiller, C. X. Santos, A. Pooni, X. Yin, K. Theofilatos, S. Cellone Trevelin, L. Zeng, G. E. Mann, A. Margariti, M. Mayr, A. M. Shah, M. Giacca, A. Zampetaki

This study uses human blood vessel organoids to show that CTGF is critical for maintaining microvascular integrity under metabolic stress.

bioRxiv · Sep 1, 2022Cell Biology

Inhibiting Runx1 protects heart function after myocardial infarction

T. P. Martin, E. A. MacDonald, A. Bradley, H. Watson, P. Saxena, E. A. Rog-Zielinska, S. Fisher, A. A. M. Elbassioni, O. Almuzaini, C. Booth, M. Campbell, P. Herzyk, K. Blyth, C. Nixon, L. Zentilin, , C. M. Loughrey

This study shows that inhibiting RUNX1 improves heart function after myocardial infarction by preserving contractility and mitochondrial function.

bioRxiv · Feb 17, 2022 · PreprintPathology

Nrf2 attenuates the innate immune response after experimental myocardial infarction

D. I. Bromage, S. C. Trevelin, J. Huntington, V. Yang, A. Muthukumar, S. Mackie, G. Sawyer, X. Zhang, C. Santos, N. Safinia, I. Smyrnias, M. Giacca, A. Ivetic, A. Shah

This study shows that Nrf2 reduces inflammation after myocardial infarction by suppressing pro-inflammatory cytokines and chemokines in mice.

bioRxiv · Jan 10, 2022Immunology

SARS-CoV-2 Spike protein activates TMEM16F-mediated platelet pro-coagulant activity

A. Cappelletto, H. E. Allan, M. Crescente, E. Schneider, R. Bussani, H. Ali, I. Secco, S. Vodret, R. Simeone, L. Mascaretti, S. Zacchigna, T. D. Warner, M. Giacca

This paper shows that SARS-CoV-2 Spike protein activates TMEM16F in platelets, enhancing pro-coagulant activity and thrombosis, which is inhibited by Niclosamide and Clofazimine.

bioRxiv · Dec 14, 2021 · PreprintPathology

The furin cleavage site of SARS-CoV-2 spike protein is a key determinant for transmission due to enhanced replication in airway cells.

T. P. Peacock, D. H. Goldhill, J. Zhou, L. Baillon, R. Frise, O. C. Swann, R. Kugathasan, R. Penn, J. C. Brown, R. Y. Sanchez-David, L. Braga, M. K. Williamson, J. A. Hassard, E. Staller, B. Hanley, , W. S. Barclay

This study shows the furin cleavage site in SARS-CoV-2 spike protein enhances replication in airway cells, contributing to transmission efficiency.

bioRxiv · Sep 30, 2020 · PreprintMicrobiology

CRISPR-Csy4-mediated editing of rotavirus double-stranded RNA genome

G. Papa, L. Venditti, L. Braga, E. Schneider, M. Giacca, G. Petris, O. R. Burrone

This study uses CRISPR-Csy4 to edit rotavirus dsRNA genome, enabling labeling of secondary transcription products and insights into viral replication.

bioRxiv · Mar 9, 2020Microbiology

Glucocorticoid Receptor ablation promotes cardiac regeneration by hampering cardiomyocyte terminal differentiation

N. Pianca, F. Pontis, M. Chirivi, V. Papa, L. Braga, R. S. Patnala, C. Bongiovanni, M. Mazzeschi, K. B. Umansky, G. Cenacchi, M. Lauriola, M. Giacca, R. Rizzi, E. Tzahor, G. D'Uva

This study shows that glucocorticoid receptor ablation enhances cardiac regeneration by reducing cardiomyocyte terminal differentiation and promoting proliferation after myocardial infarction.

bioRxiv · Jan 15, 2020Cell Biology