Author

D. L. Roden

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 8

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 7 Research Focus:cell type annotation· 6 Research Focus:differential expression· 6 Research Focus:gene regulatory network inference· 4 Assay:bulk RNA-seq· 3 Research Focus:cell-cell communication· 3 Assay:scRNA-seq· 3

Frequent Co-Authors

A. Swarbrick· 7 shared C.-L. Chan· 5 shared G. Al-Eryani· 5 shared A. S. Cazet· 4 shared K. Harvey· 4 shared N. Bartonicek· 4 shared S. Junankar· 4 shared S. Z. Wu· 4 shared

Activity by Year

2019-2023 · peak 5/yr

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10 top collaborators · 45 mutual co-author links

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7 shared papersCancer Biology

A. Swarbrick

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8 papers

Recent·Most cited

An experimental comparison of the Digital Spatial Profiling and Visium spatial transcriptomics technologies for cancer research

T. Wang, K. Harvey, J. Reeves, D. L. Roden, N. Bartonicek, J. Yang, G. Al-Eryani, D. Kaczorowski, C.-L. Chan, J. Powell, S. O'Toole, E. Lim, A. Swarbrick

This study compares Digital Spatial Profiling and Visium spatial transcriptomics technologies for cancer research, finding differences in sensitivity, specificity, and application suitability.

bioRxiv · Apr 6, 2023 · PreprintCancer Biology

DNA barcoding reveals ongoing immunoediting of clonal cancer populations during metastatic progression and in response to immunotherapy

L. A. Baldwin, N. Bartonicek, J. Yang, S. Z. Wu, N. Deng, D. L. Roden, C.-L. Chan, G. Al-Eryani, D. J. Zanker, B. S. Parker, A. Swarbrick, S. Junankar

This study uses DNA barcoding to track clonal evolution in breast cancer during metastasis and immunotherapy, finding ongoing immunoediting and identifying potential therapeutic targets.

bioRxiv · Jan 11, 2021Cancer Biology

Spatial Deconvolution of HER2-positive Breast Tumors Reveals Novel Intercellular Relationships

A. E. V. Andersson, L. Larsson, L. Stenbeck, F. Salmen, A. Ehinger, S. Z. Wu, G. Al-Eryani, D. L. Roden, A. Swarbrick, A. Borg, J. Frisen, C. Engblom, J. Lundeberg

This study uses spatial transcriptomics to analyze HER2-positive breast tumors, revealing novel intercellular relationships and developing a model for tertiary lymphoid structures across tissues.

bioRxiv · Jul 14, 2020 · PreprintCancer Biology

Single-cell analysis reveals diverse stromal subsets associated with immune evasion in triple-negative breast cancer

S. Z. Wu, D. L. Roden, C. Wang, H. Holliday, K. Harvey, A. S. Cazet, K. J. Murphy, B. Pereira, G. Al-Eryani, N. Bartonicek, R. Hou, J. R. Torpy, S. Junankar, C.-L. Chan, E. Lam, , A. Swarbrick

This study identifies diverse stromal subsets in TNBC using single-cell RNA-seq and links them to immune evasion mechanisms and therapeutic targets.

bioRxiv · Jun 4, 2020Cancer Biology

Cryopreservation of human cancers conserves tumour heterogeneity for single-cell multi-omics analysis

S. Z. Wu, D. L. Roden, G. Al-Eryani, N. Bartonicek, K. Harvey, A. S. Cazet, C.-L. Chan, S. Junankar, M. N. Hui, E. Millar, J. Beretov, L. Horvath, A. M. Joshua, P. Stricker, J. S. Wilmott, , A. Swarbrick

This study shows that cryopreservation of human cancers preserves tumour heterogeneity for single-cell multi-omics analysis, with comparable results to fresh tissue.

bioRxiv · Jun 4, 2020Cancer Biology

Single cell transcriptomics reveals involution mimicry during the specification of the basal breast cancer subtype

F. Valdes-Mora, R. Salomon, B. S. Gloss, A. M. Law, L. Castillo, K. Murphy, J. Venhuizen, A. Magenau, M. Papanicolau, L. Rodriguez de la Fuente, D. L. Roden, Y. Colino-Sanguino, Z. Kikhtyak, N. Farbehi, J. R. Conway, , D. Gallego-Ortega

The paper uses single-cell RNA sequencing to show that basal breast cancer cells mimic involution processes, involving interactions with the tumor microenvironment to promote progression.

bioRxiv · May 16, 2020Cancer Biology

Id proteins promote a cancer stem cell phenotype in triple negative breast cancer via negative regulation of Robo1

W. S. Teo, H. Holliday, N. Karthikeyan, A. S. Cazet, D. L. Roden, K. Harvey, C. V. Konrad, R. Murali, B. A. Varghese, A. P. T., C.-L. Chan, A. McFarland, S. Junankar, S. Ye, J. Yang, , R. Nair

This study shows that Id proteins promote a cancer stem cell phenotype in triple negative breast cancer by negatively regulating Robo1, leading to Myc activation.

bioRxiv · Mar 11, 2020 · PreprintCancer Biology

Targeting the Id1-Kif11-Aurka axis in triple negative breast cancer using combination therapy

R. Murali, B. A. Varghese, N. Karthikeyan, A. P. T, W. S. Teo, A. McFarland, D. L. Roden, H. Holliday, C. Konrad, A. S. Cazet, E. Dodson, J. T. George, H. Levine, M. K. Jolly, A. Swarbrick, R. Nair

This paper investigates how Id1 and Id3 maintain chemoresistant CSCs in TNBC by targeting Kif11 and Aurka, and explores combination therapy to enhance tumor debulking.

bioRxiv · Sep 11, 2019 · PreprintCancer Biology