D. Mai

Exposure to mycobacterium remodels alveolar macrophages and the early innate response to Mycobacterium tuberculosis infection

This study shows that prior exposure to mycobacteria remodels alveolar macrophages, enhancing their pro-inflammatory response to Mtb infection through both intrinsic changes and environmental factors.

Dynamics and impacts of transposable element proliferation during the Drosophila nasuta species group radiation

This study analyzes TE proliferation in seven Drosophila species, finding associations between TE insertion frequency, gene expression, and evolutionary dynamics.

Neo-sex chromosome evolution shapes sex-dependent asymmetrical introgression barrier

This study examines how neo-sex chromosome evolution creates sex-dependent asymmetrical introgression barriers in a hybrid swarm of Drosophila species.

Molecular characterization of inversion breakpoints in the Drosophila nasuta species group

The paper characterizes chromosomal inversions in the Drosophila nasuta species group using reference-quality assemblies and ancestral karyotype reconstruction, identifying inversion breakpoints and their association with repeated sequences.

Alveolar macrophages up-regulate a non-classical innate response to Mycobacterium tuberculosis infection in vivo

Alveolar macrophages infected with Mtb in vivo up-regulate an Nrf2-dependent antioxidant response instead of a pro-inflammatory response, impairing bacterial control.

An essential mycolate remodeling program for mycobacterial adaptation in host cells

The paper introduces Path-seq to study MTB transcription in host cells and identifies a mycolate remodeling program regulated by MadR during infection.

Latent Mycobacterium tuberculosis infection provides protection for the host by changing the activation state of the innate immune system

This study shows that latent Mycobacterium tuberculosis infection protects hosts by altering the activation state of the innate immune system in both mice and humans.