Cell of origin alters myeloid-mediated immunosuppression in lung adenocarcinoma
M. Yang, N. Shulkin, E. Gonzalez, J. Castillo, C. Yan, K. Zhang, L. Arvanitis, Z. Borok, W. D. Wallace, D. Raz, E. T. R. Torres, C. N. Marconett
This study shows that the cell of origin in lung adenocarcinoma affects the immunosuppressive state of the tumor microenvironment, with AT1-derived tumors showing an anti-tumor immune profile and AT2-derived tumors showing immunosuppressive features.
bioRxiv · Jun 19, 2024 · PreprintCancer Biology