Author

D. Schipper

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 7 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 8 Organism:human· 5 Assay:bulk RNA-seq· 1 Organism:mouse· 1 Organism:non-human primate· 1 Assay:organoid / primary culture· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Z. Mykytyn· 7 shared M. M. Lamers· 7 shared T. I. Breugem· 7 shared B. L. Haagmans· 6 shared P. B. van den Doel· 6 shared T. Bestebroer· 5 shared M. Koopmans· 4 shared K. Knoops· 3 shared

Activity by Year

2020-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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7 shared papersMicrobiology

A. Z. Mykytyn

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Omicron BA.1 and BA.2 are antigenically distinct SARS-CoV-2 variants

A. Z. Mykytyn, M. Rissmann, A. Kok, M. Rosu, D. Schipper, T. I. Breugem, P. B. van den Doel, F. Chandler, T. Bestebroer, M. de Wit, M. E. van Royen, R. Molenkamp, B. Oude Munnink, R. D. de Vries, C. GeurtsvanKessel, , B. Haagmans

This study compares the antigenic differences between SARS-CoV-2 Omicron BA.1 and BA.2 variants using antigenic cartography and hamster sera, finding they are distinct antigenic outliers.

bioRxiv · Feb 23, 2022 · PreprintMicrobiology

SARS-CoV-2 Omicron efficiently infects human airway, but not alveolar epithelium

M. M. Lamers, A. Z. Mykytyn, T. I. Breugem, N. Groen, K. Knoops, D. Schipper, R. van Acker, P. B. van den Doel, T. Bestebroer, C. D. Koopman, C. Reusken, M. J. Muraro, C. H. GeurtsvanKessel, M. E. van Royen, P. J. Peters, , B. L. Haagmans

This study compares the replication efficiency of SARS-CoV-2 Omicron with earlier variants in human airway and alveolar epithelial cells, finding higher replication in airways and reduced replication in alveolar type 2 cells.

bioRxiv · Jan 19, 2022 · PreprintMicrobiology

Human organoid systems reveal in vitro correlates of fitness for SARS-CoV-2 B.1.1.7

M. M. Lamers, T. I. Breugem, A. Z. Mykytyn, Y. Wang, N. Groen, K. Knoops, D. Schipper, J. van der Vaart, C. D. Koopman, J. Zhang, D. C. Wu, P. B. van den Doel, T. Bestebroer, C. C. GeurtsvanKessel, P. J. Peters, , B. L. Haagmans

The paper assesses the replicative fitness of SARS-CoV-2 B.1.1.7 variant in human organoid models and finds higher infectious virus production and fitness compared to an ancestral strain.

bioRxiv · May 3, 2021 · PreprintMicrobiology

Human airway cells prevent SARS-CoV-2 multibasic cleavage site cell culture adaptation

M. M. Lamers, A. Z. Mykytyn, T. I. Breugem, Y. Wang, D. C. Wu, S. Riesebosch, P. B. van den Doel, D. Schipper, T. Bestebroer, N. C. Wu, B. L. Haagmans

The paper shows that using human airway cells prevents SARS-CoV-2 from mutating its multibasic cleavage site during propagation.

bioRxiv · Jan 22, 2021Microbiology

The SARS-CoV-2 multibasic cleavage site facilitates early serine protease-mediated entry into organoid-derived human airway cells

A. Z. Mykytyn, T. I. Breugem, S. Riesebosch, D. Schipper, P. B. van den Doel, R. Rottier, M. M. Lamers, B. L. Haagmans

This study shows that the SARS-CoV-2 spike protein's multibasic cleavage site enhances entry into human airway cells via serine proteases, and that blocking these proteases inhibits infection.

bioRxiv · Sep 7, 2020Microbiology

Susceptibility of rabbits to SARS-CoV-2

A. Z. Mykytyn, M. M. Lamers, N. M. A. Okba, T. I. Breugem, D. Schipper, P. B. van den Doel, P. van Run, G. van Amerongen, L. de Waal, M. Koopmans, K. J. Stittelaar, J. van den Brand, B. L. Haagmans

This study shows rabbits can be infected with SARS-CoV-2 and shed infectious virus from the nose and throat.

bioRxiv · Aug 27, 2020Microbiology

SARS-CoV-2 Productively Infects Human Gut Enterocytes

M. M. Lamers, J. Beumer, J. van der Vaart, K. Knoops, J. Puschhof, T. I. Breugem, R. B. G. Ravelli, J. P. van Schayck, A. Z. Mykytyn, H. Q. Duimel, E. van Donselaar, S. Riesebosch, H. J. H. Kuijpers, D. Schipper, W. J. van de Wetering, , H. Clevers

The paper shows SARS-CoV-2 infects human gut enterocytes in small intestinal organoids, leading to viral replication and a strong immune response.

bioRxiv · Apr 25, 2020Cell Biology

Comparative Pathogenesis Of COVID-19, MERS And SARS In A Non-Human Primate Model

B. Rockx, T. Kuiken, S. Herfst, T. Bestebroer, M. Lamers, D. de Meulder, G. van Amerongen, J. van de Brand, N. Okba, D. Schipper, P. van Run, L. Leijten, E. Verschoor, B. Verstrepen, J. Langermans, , B. Haagmans

This study compares the pathogenesis of SARS-CoV-2, MERS-CoV, and SARS-CoV in non-human primates, showing SARS-CoV-2 causes a COVID-19-like disease with prolonged viral excretion without clinical signs.

bioRxiv · Mar 17, 2020Microbiology