Author

T. Bestebroer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 9

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:host-pathogen & immune response· 8 Organism:human· 4 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Organism:non-human primate· 1 Assay:organoid / primary culture· 1

Frequent Co-Authors

D. Schipper· 5 shared M. M. Lamers· 5 shared A. Z. Mykytyn· 4 shared B. L. Haagmans· 4 shared M. Koopmans· 4 shared P. B. van den Doel· 4 shared S. Herfst· 4 shared T. I. Breugem· 4 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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5 shared papersMicrobiology

D. Schipper

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

High number of HPAI H5 Virus Infections and Antibodies in Wild Carnivores in the Netherlands, 2020-2022

I. Chestakova, A. van der Linden, B. Bellido Martin, V. Caliendo, O. Vuong, S. Thewessen, T. Hartung, T. Bestebroer, J. Dekker, B. Jonge Poerink, A. Grone, M. Koopmans, R. Fouchier, J. van den Brand, R. S. Sikkema

The paper reports HPAI H5 virus infections and antibodies in wild carnivores in the Netherlands from 2020-2022, showing increasing infection rates and mammalian adaptation markers.

bioRxiv · May 12, 2023Microbiology

Contemporary human H3N2 influenza A viruses require a low threshold of suitable glycan receptors for efficient infection

C. M. Spruit, I. R. Sweet, T. Bestebroer, P. Lexmond, B. Qiu, M. J. Damen, R. A. Fouchier, J. Snijder, S. Herfst, G.-J. Boons, R. P. de Vries

This study shows that recent H3N2 influenza A viruses require a low threshold of glycan receptors for efficient infection, and increasing receptor numbers beyond this threshold does not improve infection efficiency.

bioRxiv · Nov 16, 2022Microbiology

Robustness of the ferret model for influenza risk assessment studies: a cross-laboratory exercise

J. A. Belser, E. H. Lau, W. Barclay, I. G. Barr, H. Chen, R. A. Fouchier, M. Hatta, S. Herfst, Y. Kawaoka, S. S. Lakdawala, L. Y. Y. Lee, G. Neumann, M. Peiris, D. R. Perez, C. J. Russell, , K. M. Septer

This study evaluates the consistency of ferret transmission experiments across laboratories for two H1N1 influenza viruses, finding concordant results and suggesting a minimum of three to five labs for reliable risk assessment.

bioRxiv · Apr 2, 2022Microbiology

Omicron BA.1 and BA.2 are antigenically distinct SARS-CoV-2 variants

A. Z. Mykytyn, M. Rissmann, A. Kok, M. Rosu, D. Schipper, T. I. Breugem, P. B. van den Doel, F. Chandler, T. Bestebroer, M. de Wit, M. E. van Royen, R. Molenkamp, B. Oude Munnink, R. D. de Vries, C. GeurtsvanKessel, , B. Haagmans

This study compares the antigenic differences between SARS-CoV-2 Omicron BA.1 and BA.2 variants using antigenic cartography and hamster sera, finding they are distinct antigenic outliers.

bioRxiv · Feb 23, 2022 · PreprintMicrobiology

SARS-CoV-2 Omicron efficiently infects human airway, but not alveolar epithelium

M. M. Lamers, A. Z. Mykytyn, T. I. Breugem, N. Groen, K. Knoops, D. Schipper, R. van Acker, P. B. van den Doel, T. Bestebroer, C. D. Koopman, C. Reusken, M. J. Muraro, C. H. GeurtsvanKessel, M. E. van Royen, P. J. Peters, , B. L. Haagmans

This study compares the replication efficiency of SARS-CoV-2 Omicron with earlier variants in human airway and alveolar epithelial cells, finding higher replication in airways and reduced replication in alveolar type 2 cells.

bioRxiv · Jan 19, 2022 · PreprintMicrobiology

Human organoid systems reveal in vitro correlates of fitness for SARS-CoV-2 B.1.1.7

M. M. Lamers, T. I. Breugem, A. Z. Mykytyn, Y. Wang, N. Groen, K. Knoops, D. Schipper, J. van der Vaart, C. D. Koopman, J. Zhang, D. C. Wu, P. B. van den Doel, T. Bestebroer, C. C. GeurtsvanKessel, P. J. Peters, , B. L. Haagmans

The paper assesses the replicative fitness of SARS-CoV-2 B.1.1.7 variant in human organoid models and finds higher infectious virus production and fitness compared to an ancestral strain.

bioRxiv · May 3, 2021 · PreprintMicrobiology

Human airway cells prevent SARS-CoV-2 multibasic cleavage site cell culture adaptation

M. M. Lamers, A. Z. Mykytyn, T. I. Breugem, Y. Wang, D. C. Wu, S. Riesebosch, P. B. van den Doel, D. Schipper, T. Bestebroer, N. C. Wu, B. L. Haagmans

The paper shows that using human airway cells prevents SARS-CoV-2 from mutating its multibasic cleavage site during propagation.

bioRxiv · Jan 22, 2021Microbiology

SARS-CoV-2 neutralizing human antibodies protect against lower respiratory tract disease in a hamster model

B. L. Haagmans, D. Noack, N. M. A. Okba, W. LI, C. Wang, T. Bestebroer, R. de Vries, S. Herfst, D. de Meulder, P. van Run, M. M. Lamers, B. Rijnders, C. Rokx, F. J. M. van Kuppeveld, F. Grosveld, , B. Rockx

This study shows that high-dose convalescent plasma or monoclonal antibodies protect hamsters from SARS-CoV-2-induced lower respiratory disease, but lower doses are ineffective.

bioRxiv · Aug 24, 2020Microbiology

Comparative Pathogenesis Of COVID-19, MERS And SARS In A Non-Human Primate Model

B. Rockx, T. Kuiken, S. Herfst, T. Bestebroer, M. Lamers, D. de Meulder, G. van Amerongen, J. van de Brand, N. Okba, D. Schipper, P. van Run, L. Leijten, E. Verschoor, B. Verstrepen, J. Langermans, , B. Haagmans

This study compares the pathogenesis of SARS-CoV-2, MERS-CoV, and SARS-CoV in non-human primates, showing SARS-CoV-2 causes a COVID-19-like disease with prolonged viral excretion without clinical signs.

bioRxiv · Mar 17, 2020Microbiology