Author

B. Rockx

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 10

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:host-pathogen & immune response· 9 Organism:mouse· 7 Organism:human· 2 Research Focus:cell type annotation· 1 Assay:imaging· 1 Approach:microscopy & imaging analysis· 1 Organism:non-human primate· 1

Frequent Co-Authors

M. Koopmans· 5 shared B. Haagmans· 4 shared D. Noack· 4 shared M. M. Lamers· 4 shared P. van Run· 4 shared S. Herfst· 4 shared B. L. Haagmans· 3 shared C. GeurtsvanKessel· 3 shared

Activity by Year

2020-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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5 shared papersMicrobiology

M. Koopmans

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10 papers

Recent·Most cited

Usutu virus and West Nile virus use a transcellular route of neuroinvasion across an in vitro model of the human blood-brain barrier

E. M. Marshall, M. Koopmans, B. Rockx

This study compares the neuroinvasion capabilities of Usutu and West Nile viruses across an in vitro blood-brain barrier model, finding USUV replicates to lower titres but induces similar immune responses.

bioRxiv · Jan 26, 2024 · PreprintMicrobiology

Differences in neuroinflammation in the olfactory bulb between D614G, Delta and Omicron BA.1 SARS-CoV-2 variants in the hamster model

L. Bauer, M. Rissmann, F. Benavides, L. Leijten, L. Begeman, E. Veldhuis Kroeze, P. van Run, M. P. G. Koopmans, B. Rockx, D. van Riel

The paper compares neuroinflammation in the olfactory bulb of hamsters infected with D614G, Delta, and Omicron BA.1 SARS-CoV-2 variants, finding differences in neuroinvasion and neurovirulence.

bioRxiv · Mar 24, 2022 · PreprintMicrobiology

Pulmonary lesions following inoculation with the SARS-CoV-2 Omicron BA.1 (B.1.1.529) variant in Syrian golden hamsters

M. Rissmann, D. Noack, D. van Riel, K. S. Schmitz, R. D. de Vries, P. van Run, M. M. Lamers, C. GeurtsvanKessel, M. Koopmans, R. Fouchier, T. Kuiken, B. Haagmans, B. Rockx

This study inoculates Syrian golden hamsters with SARS-CoV-2 Omicron BA.1 to compare its pathogenicity and viral shedding to Delta, finding reduced clinical signs and viral shedding but still pneumonia, with pre-existing immunity offering protection.

bioRxiv · Mar 15, 2022Microbiology

Omicron BA.1 and BA.2 are antigenically distinct SARS-CoV-2 variants

A. Z. Mykytyn, M. Rissmann, A. Kok, M. Rosu, D. Schipper, T. I. Breugem, P. B. van den Doel, F. Chandler, T. Bestebroer, M. de Wit, M. E. van Royen, R. Molenkamp, B. Oude Munnink, R. D. de Vries, C. GeurtsvanKessel, , B. Haagmans

This study compares the antigenic differences between SARS-CoV-2 Omicron BA.1 and BA.2 variants using antigenic cartography and hamster sera, finding they are distinct antigenic outliers.

bioRxiv · Feb 23, 2022 · PreprintMicrobiology

3D visualization of SARS-CoV-2 infection and receptor distribution in Syrian hamster lung lobes display distinct spatial arrangements

I. Tomris, K. M. Bouwman, Y. Adolfs, D. Noack, R. van der Woude, S. Herfst, G.-J. Boons, B. Haagmans, R. J. Pasterkamp, B. Rockx, R. P. de Vries

The paper uses 3D visualization to show that SARS-CoV-2 infection in Syrian hamster lungs occurs only where ACE2 and TMPRSS2 co-localize.

bioRxiv · Mar 24, 2021Microbiology

Replication kinetic, cell tropism and associated immune responses in SARS-CoV-2 and H5N1 virus infected human iPSC derived neural models

L. Bauer, B. Lendemeijer, L. Leijten, C. W. E. Embregts, B. Rockx, S. A. Kushner, F. M. S. de Vrij, D. van Riel

This study compares SARS-CoV-2 and H5N1 virus replication, cell tropism, and immune responses in human iPSC-derived neural cultures, finding sparse SARS-CoV-2 infection with immune activation versus efficient H5N1 replication.

bioRxiv · Mar 15, 2021Microbiology

Intranasal fusion inhibitory lipopeptide prevents direct contact SARS-CoV-2 transmission in ferrets

R. D. de Vries, K. S. Schmitz, F. T. Bovier, D. Noack, B. L. Haagmans, S. Biswas, B. Rockx, S. H. Gellman, C. A. Alabi, R. L. de Swart, A. MOSCONA, M. Porotto

bioRxiv · Nov 4, 2020Microbiology

SARS-CoV-2 neutralizing human antibodies protect against lower respiratory tract disease in a hamster model

B. L. Haagmans, D. Noack, N. M. A. Okba, W. LI, C. Wang, T. Bestebroer, R. de Vries, S. Herfst, D. de Meulder, P. van Run, M. M. Lamers, B. Rijnders, C. Rokx, F. J. M. van Kuppeveld, F. Grosveld, , B. Rockx

This study shows that high-dose convalescent plasma or monoclonal antibodies protect hamsters from SARS-CoV-2-induced lower respiratory disease, but lower doses are ineffective.

bioRxiv · Aug 24, 2020Microbiology

SARS-CoV-2 is transmitted via contact and via the air between ferrets.

M. Richard, A. Kok, D. de Meulder, T. M. Bestebroer, M. M. Lamers, N. M. A. Okba, M. Fentener van Vlissingen, B. Rockx, B. L. Haagmans, M. P. G. Koopmans, R. A. M. Fouchier, S. Herfst

This study shows SARS-CoV-2 spreads via direct contact and air between ferrets, supporting social distancing measures.

bioRxiv · Apr 16, 2020Microbiology

Comparative Pathogenesis Of COVID-19, MERS And SARS In A Non-Human Primate Model

B. Rockx, T. Kuiken, S. Herfst, T. Bestebroer, M. Lamers, D. de Meulder, G. van Amerongen, J. van de Brand, N. Okba, D. Schipper, P. van Run, L. Leijten, E. Verschoor, B. Verstrepen, J. Langermans, , B. Haagmans

This study compares the pathogenesis of SARS-CoV-2, MERS-CoV, and SARS-CoV in non-human primates, showing SARS-CoV-2 causes a COVID-19-like disease with prolonged viral excretion without clinical signs.

bioRxiv · Mar 17, 2020Microbiology