W. Hou

Biochemical and functional characterization of the p.A165T missense variant of mitochondrial amidoxime-reducing component 1 in HepG2 cells

This study characterizes the p.A165T missense variant of mARC1 in HepG2 cells, showing mislocalization, reduced stability, and impaired enzymatic function, which may explain its protective effect in liver disease.

Distinct Myeloid Derived Suppressor Cell Populations Promote Tumor Aggression in Glioblastoma

This study identifies two unique myeloid-derived suppressor cell populations in glioblastoma that promote tumor growth and immune evasion.

Lung tumor-infiltrating Treg have divergent transcriptional profiles and function linked to checkpoint blockade response

The paper identifies 10 subsets of lung cancer-infiltrating Tregs, showing one subset is suppressive and linked to anti-PD-1 resistance while another is Th1-like and associated with PD-1 response.

Lineage-mosaic and mutation-patched spike proteins for broad-spectrum COVID-19 vaccine

This study develops a bivalent vaccine using lineage-mosaic and mutation-patched spike proteins that elicit broad-spectrum antibodies and protect against multiple SARS-CoV-2 variants in hamsters.

Population Transcriptome and Phenotype Reveal that Rht-D1b Contributes a Larger Seedling Root to Modern Bread Wheat

The paper investigates the impact of GR alleles on wheat root systems, finding that Rht-D1b increases seedling root size by enhancing cell length and meristem size, while Rht-B1b has no significant effect on root traits.

Recombinant chimpanzee adenovirus AdC7 expressing dimeric tandem-repeat RBD of SARS-CoV-2 spike protein protects mice against COVID-19

This study evaluates a recombinant chimpanzee adenovirus vaccine expressing a dimeric tandem-repeat RBD of SARS-CoV-2, showing enhanced immune responses and protection in mice.

Imaging transmembrane dynamics of biomolecules at live cell plasma membranes using quenchers in extracellular environment

The paper develops a method to measure subnanometer position changes of biomolecules in live cell plasma membranes using extracellular quenchers and validates it by studying peptide-induced membrane perforation.

Robust neutralization assay based on SARS-CoV-2 S-bearing vesicular stomatitis virus (VSV) pseudovirus and ACE2-overexpressed BHK21 cells

This paper develops a robust neutralization assay using SARS-CoV-2 S-bearing VSV pseudovirus and ACE2-overexpressed BHK21 cells to screen antibodies and quantify neutralizing titers.

Rapid host response to an infection with Coronavirus. Study of transcriptional responses with Porcine Epidemic Diarrhea Virus

This study compares the transcriptional responses of Vero cells infected with PEDV and MRV, finding PEDV lacks antiviral and immune effector gene activation but alters zinc finger proteins and TMPRSS13 expression.

Virus-free and live-cell visualizing SARS-CoV-2 cell entry for studies of neutralizing antibodies and compound inhibitors

This study develops a virus-free live-cell visualization system for SARS-CoV-2 entry using a fluorescent spike trimer probe, enabling analysis of neutralizing antibodies and inhibitors.

Antifeedant activities of L-arabinose to caterpillars of the cotton bollworm Helicoverpa armigera (Hübner)

This study investigates L-arabinose's antifeedant effects on cotton bollworm caterpillars, showing it deters feeding, suppresses gustatory responses, and inhibits sucrase activity.

The acetyltransferase Eco1 elicits cohesin dimerization during S phase

This study shows that Eco1-mediated acetylation promotes cohesin dimerization during S phase, which is regulated by Hos1 and Wpl1.

Myricetin Attenuates LPS-induced Inflammation in RAW 264.7 Macrophages and Mouse Models

This study shows myricetin reduces inflammation in LPS-induced RAW 264.7 macrophages and mouse models of acute lung injury by inhibiting NF-κB and MAPK pathways.