C. Roy

The T4bSS of Legionella features a two-step secretion pathway with an inner membrane intermediate for secretion of transmembrane effectors

This study investigates the secretion mechanism of transmembrane effector proteins by Legionella T4bSS, revealing a two-step process involving an inner membrane intermediate.

Peribacillus frigoritolerans T7-IITJ, a potential biofertilizer, induces plant growth-promotinggenes of Arabidopsis thaliana

This study identifies Peribacillus frigoritolerans T7-IITJ as a biofertilizer that promotes plant growth and drought tolerance by inducing specific genes in Arabidopsis thaliana.

Synergistic activity of IL-2 mutein with tolerogenic ImmTOR nanoparticles leads to massive expansion of antigen-specific Tregs and protection against autoimmune disease

This study shows that combining IL-2 mutein with ImmTOR nanoparticles expands antigen-specific Tregs and protects against autoimmune diseases.

Designer grass pea for transgene-free minimal neurotoxin-containing seeds with CRISPR-Cas9

This study uses CRISPR-Cas9 to create grass pea plants with minimal neurotoxin {beta}-ODAP in seeds, achieving 99% reduction without transgenes.

Cytokine profiles in adults with imported malaria: insights from the PALUREA cohort study

This study analyzes cytokine profiles in adults with imported Plasmodium falciparum malaria, finding that IL-10 and MIF are associated with disease severity and nosocomial infections.

Developmental transitions coordinate assembly of the Coxiella burnetii Dot/Icm type IV secretion system

This study uses cryo-ET to show that the Dot/Icm T4SS assembles during the transition from large to small cell variants in Coxiella burnetii.

Thermal endurance by a hot-spring-dwelling phylogenetic relative of the mesophilic Paracoccus

This study identifies a thermophilic strain SMMA_5, a phylogenetic relative of Paracoccus, capable of surviving high temperatures and shows how thermal conditioning and environmental solutes enhance its thermal endurance.

DAF-2/insulin IGF-1 receptor regulates mobility during ageing by integrating opposite inputs from muscle and neuronal tissues

This paper investigates how DAF-2/insulin IGF-1 receptor regulates mobility during ageing by showing opposing effects from muscle and neuronal tissues, independent of lifespan regulation.

Glutathione regulates transcriptional activation of iron transporters via S-nitrosylation of bHLH factors to modulate subcellular iron homeostasis

This study shows glutathione regulates subcellular iron homeostasis under iron deficiency by activating iron transporters through S-nitrosylation of bHLH transcription factors.

Morningness-eveningness assessment from mobile phone communication analysis

This study uses mobile phone communication data to assess chronotypes, finding age and gender differences in morningness-eveningness and sleep patterns.

Adjuvanting a subunit SARS-CoV-2 nanoparticle vaccine to induce protective immunity in non-human primates

This study evaluates adjuvants for a subunit SARS-CoV-2 nanoparticle vaccine in non-human primates, showing durable neutralizing antibody responses and protection against infection.

Sedimentation rate and organic matter dynamics shape microbiomes across a continental margin

The paper examines how sedimentation rates and organic matter dynamics influence microbiome structure and function in different oxygen minimum zones along the Arabian Sea margin.

Osr40g3 imparts salt tolerance by regulating GF14e-mediated gibberellin metabolism to activate EG45 in rice

This study identifies Osr40g3 as a gene that enhances salt tolerance in rice by regulating gibberellin metabolism through interactions with OsGF14e and OsEG45.

Jacalin domain-containing protein OsSalT interacts with OsDREB2A and OsNAC1 to impart drought stress tolerance in planta

Rice lectin protein Osr40c1 imparts drought tolerance by modulating OsSAM2, OsSAP8 and chromatin-associated proteins

This study identifies Osr40c1 as a rice lectin protein that enhances drought tolerance by modulating OsSAM2, OsSAP8, OsMNB1B, and OsH4, which regulate downstream gene expression and polyamine biosynthesis.

Identifying Clostridioides difficile-inhibiting gut commensals using culturomics, phenotyping, and combinatorial community assembly

The paper identifies gut commensals that inhibit C. difficile using culturomics, phenotyping, and combinatorial community assembly, showing that species composition and mix size affect inhibition.

Metabolically-active obligate aerobes in anoxic (sulfidic) marine sediments

The paper identifies metabolically-active obligate aerobes in anoxic marine sediments by combining culture-dependent and -independent methods, revealing their survival through cryptic oxygen production.

Cryptic role of tetrathionate in the sulfur cycle: A study from Arabian Sea oxygen minimum zone sediments

The paper investigates the role of tetrathionate in the sulfur cycle of Arabian Sea OMZ sediments, revealing its microbial and geochemical sources and transformations.

Inorganic salts and compatible solutes help mesophilic bacteria inhabit the high temperature waters of a Trans-Himalayan sulfur-borax spring

The paper investigates how inorganic salts and compatible solutes enable mesophilic bacteria to thrive in high-temperature Trans-Himalayan hot springs by stabilizing macromolecules and maintaining cell viability.