E. C. Lien

The Caenorhabditis elegans bacterial microbiome influences microsporidia infection through nutrient limitation and inhibiting parasite invasion

The paper shows that certain bacteria reduce microsporidia infection in C. elegans by altering host metabolism and producing inhibitory compounds.

Lipid availability influences ferroptosis sensitivity in cancer cells by regulating polyunsaturated fatty acid trafficking

The paper shows lipid-starved cancer cells are more sensitive to ferroptosis due to increased PUFA trafficking into phospholipids, challenging the assumption that PUFA levels directly determine ferroptosis susceptibility.

Effects of aging on glucose and lipid metabolism in mice

This study examines how aging affects glucose and lipid metabolism in mice, finding that NAD+ levels remain stable but lipid metabolism increases in aged tissues.

NF1 deficiency drives metabolic reprogramming in ER+ breast cancer

This study investigates how NF1 deficiency affects metabolic reprogramming in ER+ breast cancer and identifies potential therapeutic synergies between metabolic and targeted inhibitors.

A CRISPRi/a screening platform to study cellular nutrient transport in diverse microenvironments

This study uses a CRISPRi/a screening platform to identify nutrient transporters critical for cancer cell proliferation in diverse microenvironments and reveals their functional roles.

Cancer cells depend on environmental lipids for proliferation when electron acceptors are limited

This study shows that cancer cells rely on environmental lipids for proliferation under conditions of limited electron acceptors, such as hypoxia or mitochondrial inhibition.

Dissecting cell type-specific metabolism in pancreatic ductal adenocarcinoma

The paper uses isotope tracing to compare metabolism between cancer cells and fibroblasts in pancreatic tumors, identifying key metabolic dependencies in cancer cells.

Caloric restriction alters lipid metabolism to contribute to tumor growth inhibition

This study shows caloric restriction inhibits tumor growth by reducing lipid availability and impairing stearoyl-CoA desaturase activity in cancer cells.