E. Coyaud

Adenomatous polyposis coli (APC) regulates internalization and signaling of the chemorepellent receptor, Roundabout (ROBO) 1

This study identifies APC's role in SLIT2-induced ROBO1 endocytosis and its impact on cell morphology.

The maintenance of centriole appendages and motile cilia basal body anchoring relies on TBCCD1

This study identifies TBCCD1 as essential for centriole appendage assembly and maintenance, and for anchoring motile cilia basal bodies, with implications for ciliopathy networks.

GEMC1 and MCIDAS interactions with SWI/SNF complexes regulate the multiciliated cell-specific transcriptional program

This study identifies distinct interactions of GEMC1 and MCIDAS with SWI/SNF subcomplexes in multiciliated cell differentiation and shows that these interactions are required for MCC-specific transcriptional regulation.

Aberrant DNA repair is a vulnerability in histone H3.3-mutant brain tumors

The paper identifies aberrant DNA repair as a vulnerability in H3.3-mutant brain tumors, showing that PNKP-mediated repair is specific to mutant cells and offers therapeutic potential.

SUMOylation of ABCD3 restricts bile acid synthesis and regulates metabolic homeostasis

This study identifies MAPL's role in regulating bile acid synthesis and metabolic homeostasis, showing its loss leads to insulin sensitivity and hepatocellular carcinoma.

LUZP1 and the tumour suppressor EPLIN are negative regulators of primary cilia formation

This study identifies LUZP1 and EPLIN as negative regulators of primary cilia formation by modulating actin dynamics at the centrosome and basal body.

Super-resolution Molecular Map of Basal Foot Reveals Novel Cilium in Airway Multiciliated Cells

The paper uses super-resolution imaging to reveal a novel hybrid cilium in airway multiciliated cells and its role as a signaling center.