Author

H. Funabiki

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Biophysics· 1 Evolutionary Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3 Research Focus:chromatin & epigenetic regulation· 3 Assay:DNA methylation· 3 Assay:ChIP-seq· 2 Research Focus:clustering· 2 Assay:cryo-EM· 2

Frequent Co-Authors

Y. Arimura· 3 shared C. Zierhut· 2 shared A. Ordureau· 1 shared A. Scelfo· 1 shared A. Smogorzewska· 1 shared A. Tan· 1 shared A. Vannini· 1 shared B. Dekker· 1 shared

Activity by Year

2017-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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3 shared papersBiophysics

Y. Arimura

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Author profile →

8 papers

Recent·Most cited

Architecture and flexibility of native kinetochores revealed by structural studies utilizing a thermophilic yeast

D. J. Barrero, S. S. Wijeratne, X. Zhao, G. F. Cunningham, R. Yan, C. R. Nelson, Y. Arimura, H. Funabiki, C. L. Asbury, Z. Yu, R. Subramanian, S. Biggins

This study reveals the architecture and flexibility of native kinetochores using structural analyses of purified kinetochores from thermophilic yeast.

bioRxiv · Feb 28, 2024 · PreprintBiophysics

Coevolution of the CDCA7-HELLS ICF-related nucleosome remodeling complex and DNA methyltransferases

H. Funabiki, I. E. Wassing, Q. Jia, J.-D. Luo, T. Carroll

This study examines the coevolution of CDCA7, HELLS, and DNA methyltransferases, finding that their presence-absence patterns are non-random and linked across species.

bioRxiv · Jan 30, 2023 · PreprintEvolutionary Biology

Vaccinia E5 is a major inhibitor of the DNA sensor cGAS

N. Yang, Y. Wang, P. Dai, T. Li, C. Zierhut, A. Tan, T. Zhang, H. Pan, Z. Li, A. Ordureau, J. Z. Xiang, R. C. Hendrickson, H. Funabiki, Z. Chen, L. Deng

This study identifies Vaccinia E5 as a major inhibitor of the cGAS-STING pathway by promoting cGAS degradation through proteasome-dependent ubiquitination.

bioRxiv · Oct 25, 2021 · PreprintMicrobiology

Structural Mechanics of the Alpha-2-Macroglobulin Transformation

Y. Arimura, H. Funabiki

This study reports cryo-EM structures of A2Moo to elucidate the structural transformation and protease entrapment mechanism.

bioRxiv · Sep 22, 2021Immunology

Linker histone H1.8 inhibits chromatin-binding of condensins and DNA topoisomerase II to tune chromosome length and individualization

P. Choppakatla, B. Dekker, E. Cutts, A. Vannini, J. Dekker, H. Funabiki

This study shows H1.8 inhibits condensins and topo II to regulate chromosome length and individualization during mitosis.

bioRxiv · Dec 20, 2020Cell Biology

Nucleosome structural variations in interphase and metaphase chromosomes

Y. Arimura, R. M. Shih, R. Froom, H. Funabiki

This study reports cryo-EM structures of nucleosomes from interphase and metaphase chromosomes, revealing greater structural uniformity in chromosomal nucleosomes compared to free mono-nucleosomes.

bioRxiv · Nov 12, 2020Cell Biology

CENP-A chromatin prevents replication stress at centromeres to avoid structural aneuploidy

S. Giunta, S. Herve, R. R. White, T. Wilhelm, M. Dumont, A. Scelfo, R. Gamba, C. K. Wong, G. Rancati, A. Smogorzewska, H. Funabiki, D. Fachinetti

This study shows that CENP-A chromatin prevents replication stress at centromeres, reducing structural aneuploidy by safeguarding DNA replication of alpha-satellite repeats.

bioRxiv · Sep 1, 2020Cell Biology

The cytoplasmic DNA sensor cGAS promotes mitotic cell death

C. Zierhut, H. Funabiki

This paper shows that cGAS promotes mitotic cell death during prolonged arrest, acting as a guardian against mitotic errors and impacting cell fate in response to anti-mitotic drugs.

bioRxiv · Jul 25, 2017Cell Biology