M. Kern

Control of cholesterol-induced adipocyte inflammation by the Nfe2l1-Atf3 pathway

This study identifies the Nfe2l1-Atf3 pathway as a regulator of cholesterol-induced adipocyte inflammation and insulin resistance in both human and mouse models.

FAM104 proteins promote the nuclear localization of p97/VCP

This study identifies FAM104 proteins as novel p97 interactors that facilitate nuclear import and chromatin binding of p97, highlighting their role in cellular processes and disease.

Cryo-electron tomography sheds light on the largest protein in the Trypanosoma brucei tripartite attachment complex

This study uses cryo-electron tomography to analyze the tripartite attachment complex in Trypanosoma brucei, revealing the structural dynamics of the complex during kDNA segregation.

Postural Sway is not affected by estrogen fluctuations during the menstrual cycle

This study examines the relationship between estrogen levels and postural sway in women, finding no significant effect of menstrual cycle phase or estradiol levels on sway.

Actin nano-architecture of phagocytic podosomes

The paper uses advanced microscopy techniques to characterize the structure of phagocytic podosomes during frustrated phagocytosis, revealing their unique actin architecture and associated protein distributions.

Long-term ecosystem nitrogen limitation from foliar δ15N data and a land surface model

The paper uses a land surface model and foliar nitrogen isotope data to assess global nitrogen limitation, finding that leaf δ15N trends cannot alone determine nitrogen limitation and that model integration reveals underlying drivers.

Correlating nuclear morphology and external force with combined atomic force microscopy and light sheet imaging separates roles of chromatin and lamin A/C in nuclear mechanics

The paper uses AFM-LS to correlate nuclear morphology and external force, revealing distinct roles of chromatin and lamin A/C in nuclear mechanics.

Validity of the Lumen(R) hand-held metabolic device to measure fuel utilization in healthy young adults

This study validates a hand-held device (Lumen(R)) for measuring metabolic fuel utilization by comparing its %CO2 readings to gold-standard metabolic cart RER values in healthy adults.

EHD2-mediated restriction of caveolar dynamics regulates cellular lipid uptake

This study shows that EHD2 restricts caveolar dynamics to regulate lipid uptake, with loss of EHD2 leading to increased fat accumulation and obesity in mice.