RIP1 kinase activity promotes steatohepatitis through mediating cell death and inflammation in macrophages
L. Tao, Y. Yi, Y. Chen, H. Zhang, J. Jie, W. Zhang, Q. Xu, Y. Li, P. Orning, E. Lien, M. Zhao, P. Gao, L. Ling, Z. Ding, C. Wu, , D. Weng
This study shows that RIP1 kinase activity in macrophages drives steatohepatitis by promoting cell death and inflammation, and its inhibition reduces liver injury in NASH models.
bioRxiv · Jan 7, 2020Immunology