Y. Yi

Development of a humanized anti-FABP4 monoclonal antibody for treatment of breast cancer

This paper develops humanized anti-FABP4 monoclonal antibodies that inhibit breast cancer tumor growth and metastasis by targeting FABP4's role in lipid metabolism.

Role of Hepatocyte RIPK1 in Maintaining Liver Homeostasis during Metabolic Challenges

This study identifies RIPK1 in hepatocytes as critical for maintaining liver homeostasis during metabolic challenges, showing its role in preventing inflammation and apoptosis in mice.

Mesenchymal stem cell-derived extracellular vesicles attenuate symptoms in dextran sodium sulfate-induced ulcerative colitis mouse model

This study shows that mesenchymal stem cell-derived extracellular vesicles reduce symptoms in a dextran sulfate sodium-induced ulcerative colitis mouse model by repairing colon mucosa and reducing macrophage infiltration.

Therapeutic targeting of KRAS mutation-driven tumorigenesis by extracellular vesicles loaded with small interfering RNA

This study demonstrates that extracellular vesicles loaded with KRAS-targeting siRNA can inhibit tumor growth in mouse models, both intratumorally and intravenously.

Harnessing extracellular vesicles for efficient siRNA delivery in vitro and in vivo

This study develops an efficient siRNA delivery system using extracellular vesicles, demonstrating effective gene silencing in vitro and tumor growth inhibition in vivo.

Signal Improved ultra-Fast Light-sheet Microscope (SIFT) for large tissue imaging

The paper introduces an improved light-sheet microscope that increases imaging speed and signal strength for large tissue samples.

Living cell mTORC1 inhibition reporter mTIR reveals nutrient-sensing targets of histone deacetylase inhibitor

The paper introduces a genetically encoded mTORC1 inhibition reporter, mTIR, which identifies histone deacetylase inhibitors that selectively target mTORC1 through nutrient-sensing gene expression.

Epigenetic Landscape of HIV Infection in Primary Human Macrophage

This study examines the epigenetic changes in HIV-infected primary human macrophages, revealing a unique non-canonical bivalent epigenetic state and active viral transcription despite heterochromatin marks.

The influence factors of mean particle size and positive quality control of bacterial filtration efficiency system

This study identifies key factors affecting bacterial aerosol mean particle size and positive quality control value in BFE systems, finding optimal parameters for performance.

Transcriptome analysis reveals regulatory networks and hub genes in flavonoid metabolism of Rosa roxburghii

This study identifies key genes and regulatory networks in flavonoid metabolism of Rosa roxburghii using transcriptome analysis and WGCNA.

Hydroxyl-radical scavenging activity of hydrogen does not significantly contribute to its biological function

This study challenges the idea that hydrogen's antioxidant properties are its main biological function by showing limited hydroxyl radical scavenging and suggesting alternative mechanisms.

Self-assembling SARS-CoV-2 nanoparticle vaccines targeting the S protein induces protective immunity in mice

This study develops self-assembling SARS-CoV-2 nanoparticle vaccines that induce protective immunity in mice through subcutaneous and oral administration.

Evaluation of exosome-encapsulated miR-23a/b in the diagnosis of human coronary heart diseases

This study evaluates serum exosomal miR-23a and miR-23b as biomarkers for diagnosing coronary heart diseases, finding miR-23a is downregulated and predictive of stable angina and AMI.

Recombinant SARS-CoV-2 RBD molecule with a T helper epitope as a built in adjuvant induces strong neutralization antibody response

This study develops a recombinant SARS-CoV-2 RBD molecule fused with a T helper epitope as an adjuvant, showing strong neutralizing antibody response in mice.

A hybrid open-top light-sheet microscope for multi-scale imaging of cleared tissues

The paper introduces a hybrid light-sheet microscope that enables versatile multi-scale imaging of cleared tissues with varying resolution, geometry, and compatibility requirements.

Identification of genes required for enzalutamide resistance in castration-resistant prostate cancer cells in vitro

This study identifies three genes (ACAT1, MAP3K11, and PSMD12) that support enzalutamide resistance in castration-resistant prostate cancer cells in vitro.

Effects of rhein on bile acid homeostasis in rats

This study examines the effects of rhein on bile acid homeostasis in rats, showing dose-dependent changes in bile acid levels and transporter expression without liver or kidney toxicity.

RIP1 kinase activity promotes steatohepatitis through mediating cell death and inflammation in macrophages

This study shows that RIP1 kinase activity in macrophages drives steatohepatitis by promoting cell death and inflammation, and its inhibition reduces liver injury in NASH models.

Dimethylarsenic acid (DMA) accumulation positively correlates with realgar-induced subchronic toxicity in rats

This study shows that dimethylarsenic acid (DMA) accumulation correlates with realgar-induced toxicity in rats, with liver and kidney damage reversing after drug withdrawal.