Q. Dai

Fast adaptive super-resolution lattice light-sheet microscopy for rapid, long-term, near-isotropic subcellular imaging

This paper introduces Meta-rLLS-VSIM, a super-resolution microscopy technique that achieves near-isotropic resolution with reduced training time and data requirements.

Time-lapse Image Super-resolution Neural Network with Reliable Confidence Quantification for Optical Microscopy

This paper introduces a time-lapse image super-resolution neural network with confidence quantification for optical microscopy, improving temporal consistency and reliability.

Splenic red pulp macrophages eliminate the liver-resistant Streptococcus pneumoniae during bloodstream infection

The paper identifies that splenic red pulp macrophages, aided by natural antibodies and complement, clear liver-resistant Streptococcus pneumoniae from the bloodstream in mice.

Herpes zoster mRNA vaccine induces superior vaccine immunity over licensed vaccine in mice and rhesus macaques

This study compares a novel VZV mRNA vaccine (ZOSAL) with Shingrix in mice and rhesus macaques, showing ZOSAL induces stronger T cell immunity and safety.

Enzyme-mediated alkynylation enables transcriptome-wide identification of pseudouridine modifications

The paper introduces ELAP-seq, a method to detect pseudouridine modifications in RNA with high sensitivity and resolution, identifying over 10,000 sites in human transcripts.

Spatial redundancy transformer for self-supervised fluorescence image denoising

This paper introduces SRDTrans, a self-supervised denoising transformer for fluorescence images, achieving state-of-the-art performance in single-molecule and two-photon imaging.

Zero-shot learning enables instant denoising and super-resolution in optical fluorescence microscopy

This paper introduces a zero-shot deep learning method for super-resolution microscopy that enhances resolution with less fluorescence and no training data.

Bio-friendly long-term subcellular dynamic recording by self-supervised image enhancement microscopy

This paper introduces DeepSeMi, a self-supervised denoising framework that enhances fluorescence microscopy by increasing SNR and enabling long-term, high-resolution imaging of cellular processes.

Mapping global land sharing-sparing patterns between human and wildlife

The paper maps global land sharing-sparing patterns between humans and wildlife using human-nature indices and classifies lands into four categories based on biodiversity and human pressure.

habCluster: Identifying Geographical Boundary among Intraspecific Units Using Community Detection Algorithm in R

habCluster identifies geographical boundaries of intraspecific units using a community detection algorithm, showing good alignment with nature reserves for giant pandas.

AI inspired discovery of new biomarkers for clinical prognosis of liver cancer

This paper introduces PathFinder, an interpretable AI framework for discovering new tissue biomarkers in liver cancer, identifying tumor necrosis as a prognostic factor.

Real-time denoising of fluorescence time-lapse imaging enables high-sensitivity observations of biological dynamics beyond the shot-noise limit

This paper introduces DeepCAD-RT, a real-time denoising method for fluorescence time-lapse imaging that improves signal-to-noise ratio with fewer photons, demonstrated across multiple organisms and biological processes.

Spinning Disk Multifocal Microscopy for Dynamic Arbitrarily Shaped Surface Imaging at Centimetre Scale and Micrometre Resolution

This paper introduces Spinning Disk Multifocal Microscopy (SDiM) for high-speed, high-resolution imaging of large biological surfaces, demonstrating its application in cortical and immune cell studies.

Rapid deep widefield neuron finder driven by virtual calcium imaging data

The paper introduces DeepWonder, a deep learning tool for rapid and accurate neuron detection in widefield calcium imaging data, achieving faster processing and improved signal-to-background ratio compared to traditional methods.

3D observation of large-scale subcellular dynamics in vivo at the millisecond scale

This paper introduces a method to observe 3D subcellular dynamics in vivo at high resolution and speed, demonstrating its application in various biological systems.

The METTL5-TRMT112 N6-methyladenosine methyltransferase complex regulates metabolism and development via translation

This paper identifies the METTL5-TRMT112 complex as the methyltransferase responsible for m6A modification at 18S rRNA, linking it to metabolism and development.

On the robustness of inference of association with the gut microbiota in stool, swab and mucosal tissue samples

This study compares the robustness of microbiota association inference using stool, swab, and mucosal tissue samples in a larger cohort, finding that mucosal samples yield less consistent results than stool or swab.

Computational optical sectioning by phase-space imaging with an incoherent multiscale scattering model

This paper introduces a computational method for optical sectioning using phase-space imaging with an incoherent multiscale scattering model, achieving improved signal-to-background ratio in biological samples.

A polymer gel index-matched to water enables diverse applications in fluorescence microscopy

This paper introduces a polymer gel matched to water's refractive index, enabling high-resolution imaging of living cells and organisms in thick layers.

Tethering-facilitated DNA 'opening' and complementary roles of β-hairpin motifs in the Rad4/XPC DNA damage sensor protein

This study shows Rad4/XPC can open undamaged DNA in solution without specific β-hairpin motifs and reveals dynamic conformations of open DNA through crystal structures and fluorescence analysis.

Comparison of SARS-CoV-2 infections among 3 species of non-human primates

This study compares SARS-CoV-2 infection outcomes in three non-human primate species, finding that M. mulatta is most susceptible, followed by M. fascicularis and C. jacchus.

Augmenting Vascular Disease Diagnosis by Vasculature-awareUnsupervised Learning

This paper introduces VasNet, an unsupervised learning algorithm that improves vascular disease diagnosis from unlabeled images by focusing on retinal vasculature features.

Deoxyribozyme-based Method for Site-specific Absolute Quantification of N6-methyladenosine Modification Fraction

This paper introduces a deoxyribozyme-based method to absolutely quantify m6A modification fractions at specific RNA sites using reverse transcription and qPCR.

Impact of DNA sequences in the DNA duplex opening by the Rad4/XPC nucleotide excision repair complex

This study shows that DNA sequences affect how Rad4/XPC opens DNA duplexes, with some sequences resisting opening despite prolonged Rad4 binding.

Fast, Accurate Polarization and Polarity Imaging withPolarized Structured Illumination

This paper introduces a method for fast and accurate polarization and polarity imaging using polarized structured illumination, improving measurement accuracy and speed compared to conventional techniques.

Imaging chromatin interactions at sub-kilobase resolution Via Tn5-FISH

This paper introduces Tn5-FISH, a method to visualize chromatin interactions at sub-kilobase resolution and validate results from 3C-derivative methods.

JNK-IN-8, a c-Jun N-terminal kinase inhibitor, improves functional recovery through suppressing neuroinflammation in ischemic stroke

This study shows JNK-IN-8 improves functional recovery in ischemic stroke by reducing neuroinflammation through the JNK/NF-κB pathway.

Biogenesis of a young, 22-nt microRNA in Phaseoleae species by precursor-programmed uridylation

The paper shows that miR1510 in Phaseoleae species is primarily a 22 nt isoform due to monouridylation, and demonstrates how post-processing modifications can optimize miRNA function.