A compendium of Amplification-Related Gain Of Sensitivity (ARGOS) genes in human cancer
V. Rendo, M. Schubert, N. Khuu, M. F. Suarez Peredo Rodriguez, K. Huang, M. Swift, Y. He, J. Zerbib, R. Smith, J. Raaijmakers, P. Bandopadhayay, L. M. Guenther, J. H. Hwang, A. Iniguez, S. Moody, , F. Foijer
The paper identifies ARGOS genes, which are amplified in cancer, have low expression relative to copy number, and are toxic when overexpressed, and validates several as pan-cancer targets.
bioRxiv · Dec 16, 2023 · PreprintCancer Biology