E. V. Prochownik

This study shows that inactivating the Mlx network in mice accelerates aging-related phenotypes and increases cancer risk, similar to Myc inactivation, but with different lifespan outcomes.

This study investigates the effects of near-complete Myc inactivation in mice, finding premature aging features but reduced cancer incidence and linking Myc dysregulation to aging and cancer.

This study investigates the interaction between the Myc and Mlx networks in liver regeneration and tumorigenesis, finding that the Mlx network plays a critical role in maintaining homeostasis and suppressing tumor formation.

This study shows that patient-derived NFE2L2 mutants drive aggressive hepatoblastomas in mice by accelerating tumor growth and promoting necrosis and cyst formation.

This study shows that reducing the peroxisomal enzyme Ehadh in hepatoblastoma makes tumors more susceptible to a fatty acid metabolite, suggesting a potential metabolic therapy.

The paper examines ribosomal protein transcript (RPT) expression patterns in tumors and normal tissues, showing distinct patterns that correlate with tumor subtypes, molecular features, and patient survival.