E. Yeh

Mixed Alkyl/Aryl Phosphonates Identify Metabolic Serine Hydrolases as Antimalarial Targets

The paper identifies mixed alkyl/aryl phosphonates as anti-malarial compounds that inhibit serine hydrolases with low resistance potential.

Covalent macrocyclic proteasome inhibitors mitigate resistance in Plasmodium falciparum

This paper develops covalent macrocyclic proteasome inhibitors for Plasmodium falciparum that show reduced resistance compared to reversible inhibitors.

The endosymbiont of Epithemia clementina is specialized for nitrogen fixation within a photosynthetic eukaryote

This study investigates the metabolic adaptations of a nitrogen-fixing endosymbiont in Epithemia clementina, showing its dependency on host photosynthesis and altered nitrogen regulation.

Structure-function relationship for a divergent Atg8 protein required for a non-autophagic function in malaria parasites

This paper investigates the structure-function relationship of PfAtg8, a divergent Atg8 protein in malaria parasites, showing that its non-autophagic function in apicoplast inheritance does not rely on canonical Atg8 interaction domains.

CaaX-like protease of cyanobacterial origin is required for complex plastid biogenesis in malaria parasites

The paper identifies AMR4, a CaaX-like protease in Plasmodium parasites, which is essential for apicoplast biogenesis but does not function in the expected CaaX post-prenylation pathway.

Evidence that disruption of apicoplast protein import in malaria parasites evades delayed-death growth inhibition

This study shows that disrupting apicoplast protein import in malaria parasites avoids delayed-death growth inhibition, suggesting potential for developing fast-acting antimalarials.

A mutagenesis screen for essential plastid biogenesis genes in human malaria parasites

The paper identifies essential genes for apicoplast biogenesis in P. falciparum through a mutagenesis screen, revealing new proteins and functions with potential drug targets.

Host cell metabolism contributes to delayed-death kinetics of apicoplast inhibitors in Toxoplasma gondii

This study shows that host cell metabolism rescues apicoplast defects in Toxoplasma gondii, causing delayed death after apicoplast inhibitor treatment.

Integrative proteomics and bioinformatic prediction enable a high-confidence apicoplast proteome in malaria parasites

The paper combines proteomics and machine learning to generate a high-confidence apicoplast proteome in malaria parasites, identifying 346 proteins and validating novel functions.

Atg8 is essential specifically for an autophagy-independent function in apicoplast biogenesis in blood-stage malaria parasites

This study shows that Atg8 is essential for apicoplast biogenesis in malaria parasites, specifically for its segregation during replication, independent of autophagy.

Small molecule inhibition of apicomplexan FtsH1 disrupts plastid biogenesis in human pathogens

The paper identifies FtsH1 as a novel druggable target for antimalarial drugs by showing that its inhibition disrupts apicoplast biogenesis in Plasmodium falciparum and Toxoplasma gondii.

A Specific Non-Bisphosphonate Inhibitor Of The Bifunctional Farnesyl/Geranylgeranyl Diphosphate Synthase In Malaria Parasites

This paper identifies MMV019313 as a specific non-bisphosphonate inhibitor of PfFPPS/GGPPS in malaria parasites, showing superior properties and selectivity over bisphosphonates.