Author

H.-J. Wen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Evolutionary Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

C.-I. Wu· 2 shared H. C. Crawford· 2 shared N. G. Steele· 2 shared P. Lin· 2 shared A. Andren· 1 shared A. L. Myers· 1 shared A. Robinson· 1 shared A. Steep· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersEvolutionary Biology

C.-I. Wu

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

ROR2 regulates cellular plasticity in pancreatic neoplasia and adenocarcinoma

S. Benitz, A. Steep, M. Nasser, J. Preall, U. M. Mahajan, H. McQuithey, I. Loveless, E. T. Davis, H.-J. Wen, D. W. Long, T. Metzler, S. Zwernik, M. Louw, D. Rempinski, D. Salas-Escabillas, , H. C. Crawford

This study identifies ROR2 as a regulator of cellular plasticity in pancreatic neoplasia, showing it promotes an aggressive PDAC phenotype and resistance to KRAS inhibitors.

bioRxiv · Dec 13, 2023Cancer Biology

Gene expression as phenotype - Many small-step changes leading to little long-term phenotypic evolution

P. Lin, G.-A. Lu, Z.-Q. Liufu, Y. Zhao, Y.-S. Ruan, C.-I. Wu, H.-J. Wen

The paper tests the Fishers Geometric Model postulate by analyzing gene expression data, showing that small-step evolution via miRNA regulation is common but does not lead to long-term phenotypic changes.

bioRxiv · Jun 24, 2022 · PreprintEvolutionary Biology

Homo-harringtonine (HHT) - A highly effective drug against coronaviruses and the potential for large-scale clinical applications

H.-J. Wen, P. Lin, G.-X. Zhong, Z.-C. Xu, L. Shuai, Z.-Y. Wen, C. Wang, X. Cao, W.-B. He, J. Feng, Q.-C. Cai, H.-J. Ma, S.-J. Wu, G.-D. Wang, X.-M. Lyu, , C.-I. Wu

The paper identifies Homo-harringtonine (HHT) as a potent antiviral drug against coronaviruses, effective in mouse models and safe in dogs, with potential for large-scale clinical use.

bioRxiv · Apr 16, 2021 · PreprintMicrobiology

The Pancreatic Tumor Microenvironment Compensates for Loss of GOT2

S. A. Kerk, L. Lin, A. L. Myers, Y. Zhang, J. A. Jimenez, P. Sajjakulnukit, B. S. Nelson, B. Chen, A. Robinson, G. Thurston, S. B. Kemp, N. G. Steele, M. T. Hoffman, H.-J. Wen, D. Long, , C. A. Lyssiotis

This study shows that the pancreatic tumor microenvironment compensates for loss of GOT2 by providing pyruvate, maintaining redox homeostasis and tumor growth in vivo.

bioRxiv · Aug 7, 2020Cancer Biology