K. Luo

Phosphodiesterase 1A physically interacts with YTHDF2 and reinforces the progression of non-small cell lung cancer

This study identifies PDE1A as a promoter of NSCLC metastasis through interaction with YTHDF2 and activation of the STAT3 pathway.

Targeted degradation of PRC1 components, BMI1 and RING1B, via a novel protein complex degrader strategy

This paper introduces MS147, a novel degrader of PRC1 components BMI1 and RING1B, which selectively degrades these proteins and inhibits cancer cell proliferation.

Type 17 Follicular Helper T (Tfh17) Cells are Superior for Memory Maintenance

This study shows that Tfh17 cells are more effective than Tfh1 and Tfh2 cells in maintaining memory responses after vaccination.

Zika virus-specific IgM elicited during pregnancy exhibits ultrapotent neutralization

This study identifies a potent ZIKV-neutralizing IgM antibody from a pregnant woman and shows its protective efficacy in mice.

Different adjuvanted pediatric HIV envelope vaccines induced distinct plasma antibody responses despite similar B cell receptor repertoires in infant rhesus macaques.

Heme oxygenase limits mycobacterial infection-induced ferroptosis

This study identifies zebrafish Hmox1a as a protective factor against mycobacterial infection by reducing iron accumulation and ferroptosis.

Transplantation of high fat fed mouse microbiota into zebrafish larvae identifies MyD88-dependent acceleration of hyperlipidaemia by Gram positive cell wall components

The paper transplants mouse high fat diet microbiota into zebrafish larvae to identify microbial factors that accelerate hyperlipidaemia via MyD88 signaling.

A Vaccine Composed of Antigen Fused to a Ligand for a Receptor on Immature Dendritic Cells Elicits Elevated Antibody Responses to Malaria Sporozoites in Infant Macaques

This study shows that a malaria vaccine with a specific antigen and adjuvant induces strong antibody responses in infant macaques, reducing sporozoite load and suggesting potential for human use.

Rough and smooth variant Mycobacterium abscessus infections are differentially controlled by host immunity during chronic infection of adult zebrafish

This study compares immune responses to smooth and rough variants of Mycobacterium abscessus in zebrafish, showing differential control by host immunity.

The microRNA476a/RFL module regulates adventitious root formation through a mitochondria-dependent pathway in Populus

This study identifies miR476a/RFL as a regulator of adventitious root formation in poplar through mitochondrial homeostasis and auxin pathway modulation.

Phase separation of TAZ compartmentalizes the transcription machinery to promote gene expression

This study shows TAZ uses phase separation to compartmentalize transcription factors and enhance gene expression, distinct from its paralog YAP.

Boosting with ALVAC-HIV and AIDSVAX B/E enhances Env constant region 1 and 2 antibody-dependent cellular cytotoxicity

The paper shows that boosting RV144 vaccine recipients with ALVAC-HIV and AIDSVAX B/E increases C1C2-specific antibody-dependent cellular cytotoxicity breadth and potency.

IFN-alpha and 5-Aza-2-deoxycytidine enhance the anti-tumor efficacy of a dendritic-cell targeting MIP3alpha-Gp100-Trp2 DNA vaccine by affecting T-cell recruitment and tumor microenvironment gene expression

This paper shows that combining IFN-alpha and 5-Aza-2-deoxycytidine with a MIP3alpha-Gp100-Trp2 DNA vaccine improves anti-tumor efficacy by enhancing T-cell recruitment and altering tumor microenvironment gene expression.

Comprehensive identification of survival-associated genes for cancers

The paper identifies survival-associated genes across cancers and finds twenty-two genes with both diagnostic and prognostic capacity, including universal genes linked to mutated pathways.

Characterization and mechanism of lead and zinc biosorption by growing Verticillium insectorum J3

This study investigates the biosorption of Pb(II) and Zn(II) by Verticillium insectorum J3, finding that it absorbs Pb(II) preferentially and shows enhanced biosorption at higher concentrations.