L. Williams

Solution-phase indexing by kinetic confinement enables rapid, simple, and instrument-free single cell transcriptional profiling

This paper introduces an instrument-free method for single-cell transcriptional profiling using kinetic confinement and bifunctional indexing reagents, enabling rapid and scalable analysis.

DNA origami vaccine (DoriVac) nanoparticles improve both humoral and cellular immune responses to infectious diseases

This study demonstrates that DNA origami vaccine nanoparticles enhance both humoral and cellular immune responses against infectious diseases like SARS-CoV-2, HIV, and Ebola.

Rational design of a SOCS1-edited tumor infiltrating lymphocyte therapy for solid tumors using CRISPR/Cas9 screens

This study uses CRISPR/Cas9 screens to identify SOCS1 as a target for enhancing T cell therapy, leading to the development of an engineered TIL therapy with improved anti-tumor function.

Conserved allomorphs of MR1 drive specificity of MR1-restricted TCRs

The paper shows that MR1-restricted TCRs recognize an allelic variant of MR1 (MR1*04) present in healthy individuals, indicating that these TCRs are not cancer-specific and may react to both cancer and healthy cells.

Frequent allopolyploidy with distant progenitors in the moss genera Physcomitrium and Entosthodon (Funariaceae) identified via subgenome phasing of targeted nuclear genes.

The paper identifies allopolyploidy in moss species using subgenome phasing of targeted nuclear genes, revealing hybrid origins and new lineages.

Optimizing CRE and PhiC31 mediated recombination in Aedes aegypti

This paper improves genetic manipulation techniques in Aedes aegypti by introducing transgenic lines for Cre-mediated recombination and a plasmid-based PhiC31 integrase system for stable transgene integration.

InVitro Biocompatibility Evaluation of Acellular Porcine Dura mater Grafts and Native Dura

This study evaluates the biocompatibility of native and acellular porcine dura grafts using rat fibroblast cells, showing comparable viability, proliferation, and mechanical properties to native tissue.

The City Nature Challenge - A global citizen science phenomenon contributing to biodiversity knowledge and informing local government practices

The paper evaluates the City Nature Challenge's contribution to biodiversity knowledge and local government practices through a case study and framework development.

Centriolar satellites expedite mother centriole remodeling to promote ciliogenesis.

This study shows that PCM1 and centriolar satellites are essential for efficient ciliogenesis by facilitating protein trafficking and remodeling of the mother centriole.

SARS-CoV-2-specific T cells in unexposed adults display broad trafficking potential and cross-react with commensal antigens

Design considerations of a wearable electronic-skin for mental health and wellness: balancing biosignals and human factors

The paper designs a wearable electronic-skin for mental health monitoring, finding that upper arm and forearm are optimal wear locations by balancing human factors and biosignal accuracy.

A universal scaling method for biodiversity-ecosystem functioning relationships

The paper develops a method to upscale biodiversity-ecosystem functioning relationships using macroecological patterns, showing that species-area and biomass-area curves predict biodiversity-biomass relationships at larger scales.

Reproductive longevity predicts mutation rates in primates

The paper shows that paternal age determines de novo mutation rates in owl monkeys and proposes a model linking reproductive longevity to mutation rates across primates.